I sent a Flash Alert on CombinatoRx (CRXX) earlier this morning, which announced that last Friday the FDA said Exalgo is not approvable under the current New Drug Application (NDA). Since then I have talked to the company, reviewed Neuromed’s Phase III data, and gone back to the transaction in which Neuromed acquired the U.S. rights to Exalgo from Alza Corp.
To review, Exalgo is an opiate for pain that was sold as Dilaudid for many years and is now available as a generic. Alza wrapped it in their proprietary timed release drug delivery technology, to make it a once-a-day pill for severe chronic pain, replacing the need to administer several pills each day. Alza did a Phase III trial that did not meet FDA standards for approval, so they sold the U.S. rights to Neuromed for $30 million plus royalties.
Neuromed agreed with the FDA on a Special Protocol Assessment (SPA) for a single Phase III trial that would support approval of Exalgo. When they announced the trial results in March, they said they hit their numbers for the primary endpoint of SPA, pain reduction, and that all the secondary endpoints also supported the SPA. Based on that, I thought they had a clear path to approval, with the only issues being the usual ones surrounding a Schedule II painkiller regarding controlling abuse and keeping it off the streets.
I said this morning, I didn’t think efficacy was an issue. I also didn’t think safety was an issue, because the side effects were just as expected with a strong opiate, and no different that the generic versions of Dilaudid now used. So I was puzzled by the company’s statement that they might refile under Section 505(b)2 of the Food, Drug and Cosmetic Act of 1938, which allows approval based on “an application that contains full reports of investigations of safety and effectiveness but where at least some of the information required for approval comes from studies not conducted by or for the applicant and for which the applicant has not obtained a right of reference.”
They are referring to Alza’s studies, even though those have already been reviewed by the FDA. So I am still not sure what the real issue is, and there is some chance that it could be an efficacy or safety issue that has not surfaced yet. I talked to the company and they just got the news and questions from the FDA on Friday. They will work on the data in the general areas the FDA is concerned about and then meet with the FDA in two or three weeks to agree on the detailed questions and what answers are needed to resolve them.
As I said in the earlier Flash Alert, the two companies are postponing their shareholder meetings to November 30 that were meant to vote on the merger. I also said I think it is possible that the merger will fall apart over this issue. They are not likely to have their next FDA meeting before November 30, so I’m not sure if CRXX shareholders will have enough information to vote. At the very least, the proxy has to be stickered for this new development.
CRXX had about $20 million in cash at the end of September against $6 million in accounts payable, and they burn about $8 million a quarter, so they would only have two quarters of cash left if the merger falls through. That would send the stock back to the 50 cent to 70 cent area. I thought it would be cut in half today to the 75 cent to 85 cent area, but it was able to bounce off 85 cents and is trading just under $1.
I do not want you to sell CRXX under $1. I said this morning that if you get a chance to sell it higher than $1 or so and would rather sell it and buy it back later, that strategy probably will work. However, the best strategy is to hold the stock for now, until we get more information. I do not want you to buy it or average down until the situation is clearer, so I am changing CRXX to a temporary Hold. Most likely, there will be a way to resolve this without another clinical trial that will let the merger go forward, although the combined companies will have to cut costs to meet the new FDA deadline, which will be about a year away. CRXX also has a good pipeline of drugs and will continue to try to partner anything with good Phase II results.
PLEASE DON’T POST THIS INFORMATION OR A LINK TO IT ON THE INTERNET. THANKS!
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Thanks for reacting so quickly and keeping all of us up-to-date. We appreciate it. Keep up the good work!!!
There was be some whispers about MELA. Added over $.50 to this point today. I kind of like that – offsets against CRXX!
rvn817j Reply:
November 16th, 2009 at 1:46 pm Comment # 12555
@rvn817j, Not ‘was’, meant to say ‘must’!
actionjack Reply:
November 16th, 2009 at 2:27 pm Comment # 12558
@rvn817j, Yeah up to $9 bucks now….hmmm maybe that upgrade (12.5) from last week is kicking in. The volume isnt too big for it to be a leak or anything (IMO)…
Michael,
Thank you for following up with BCRX management.
Again, I must compliment you on your work. Where else can a subscriber bring up an issue at 4:30 am, and find a response with commentary from a company’s management waiting when he gets out of bed.
As thery still say around here. “yu da man”.
Are the market makers practicing today on bcrx for option exp this friday???
As long as the BCRX shorts can play with artificial supply to provide liquidity I think the market is stable but when the liquidity dries up the explosion will take place. We have had some evidence of liquidity problems starting. Is that interest rate for shares business still being offered?
@Michael Murphy, (assuming they did not know about this before,) now that BRCX has been advised of this supposed Chinese competitor, will they have to disclose this (soon) as a material event?
dogdayaftern00nTM@gmail.com Reply:
November 16th, 2009 at 2:55 pm Comment # 12565
@LIONARY1, Lionary, why would they disclose it? They don’t seem to be too concerned about it in the first place.
Carl Flygt Reply:
November 16th, 2009 at 3:10 pm Comment # 12569
@dogdayaftern00nTM@gmail.com, Isn’t there a rule that says they have to? Seems like the SEC would want to protect investors with a rule like that.
doncl316 Reply:
November 16th, 2009 at 3:17 pm Comment # 12577
@Carl Flygt, huh? Disclose what? A report in a foreign newspaper?
This would be like Dendreon (a few years ago) having to disclose, um, CEGE might develop a product to compete with us….um, and Cougar may develop a product that might compete with us….
How does this “protect investors” – this is asking our management team to file SEC docs based on a rumors?
They have more important things to do….let’s stop the all the conspiracy stuff…
Our PPS is not being “held up” by China. It will not plunge based on this rumor.
Now, the shorts playing tricks – yes, that could provide a buying opportunity. Make sure you are ready.
regards, don
Carl Flygt Reply:
November 16th, 2009 at 4:06 pm Comment # 12599
Don, that’s fair enough, and the point is taken. But remember, both Rob Bennett and MM are now writing about HNG as a “potential competitor.” At some point that competition becomes material, and Biocryst must disclose it, right?
LIONARY1 Reply:
November 16th, 2009 at 3:10 pm Comment # 12570
@dogdayaftern00nTM@gmail.com, it’s one thing for the Company to respond to Michael in a way that seems to show that they are not particulary concerned (and maybe they are not), but I am assuming that they will still need to make the determination, sooner than later, of whether this constitutes a material event under current SEC regulations (which they would then be obligated to disclose in a current filing). And I further assume that a company would tend to be conservative in making that determination. But this is not my area of expertise, that’s why I was running it by Michael.
(Needless to say, I am concerned that if they did have to make such a filing, the uncertainty from this kind of news might adversely impact the stock, especially if the ROW orders have not yet been announced.)
rvn817j Reply:
November 16th, 2009 at 3:13 pm Comment # 12574
@dogdayaftern00nTM@gmail.com, I’m still wondering what makes this the same drug? Just because the Chinese call it peramivir, is it the exact same thing as the drug being produced by BCRX? Has anyone gotten a sample from the Chinese? Based on BCRX response, it seems that no one really knows much of anything about the Chinese drug except that the Chinese claim to have a drug called peramivir.
DR. JOHN PETERSON Reply:
November 16th, 2009 at 4:43 pm Comment # 12611
@rvn817j, Good point.
JINRNO Reply:
November 16th, 2009 at 3:50 pm Comment # 12593
@LIONARY1, IMHO I think BCRX just needs to disclose to the share holders that the Chinese Peramivir is not the same one developed in house..
LIONARY1 Reply:
November 16th, 2009 at 4:40 pm Comment # 12610
@JINRNO, frankly, I have no idea whether they have to disclose all this or not. All this sure seems awfully material to me. But on the other hand, maybe by legal standards BCRX has no obligation to react to unsubstantiated articles in newspapers or websites (at least not yet). It’s interesting that BCRX responded to Michael that “Neither BioCryst nor NT Pharma has seen OFFICIAL PRESS RELEASES from the SFDA or Chinese ministry of health regarding the testing or regulatory status of this Chinese peramvir product…”, while one of the articles claimed that “Jiangying Yan, spokesman of the State Food and Drug Administration (SFDA) announced at a ROUTINE CONFERENCE…”(emphasis added). This was a calculated response.
Mind you, it’s now been at least 3 published articles (2 of which appearing on a (general) government website). One would think/hope that at some point, BCRX will have a duty to investigate (e.g., call up the SFDA or send somebody there to investigate).
dogdayaftern00nTM@gmail.com Reply:
November 16th, 2009 at 4:43 pm Comment # 12612
@LIONARY1,
Got this from Yahoo/IV:
“Joe,
BioCryst has patent protection for peramivir composition of matter in most pharmaceutical markets. BioCryst has filed, allowed or pending patents in most other countries. In China, BioCryst has filed for a patent, but it has not been issued yet. Without one or more patent issued, it is more likely we will face competition in China.
NT Pharma is the only partner BioCryst is working with in China–we have no relationship with HNG Chembio Pharmacy or the Chinese Academy of Military Medical Sciences. NT Pharma has made progress in its discussions with the Chinese government regarding possible use of peramivir during the ongoing flu pandemic. BioCryst and NT Pharma will discuss registration strategies for peramivir in China.
Neither BioCryst nor NT Pharma has seen official press releases from the SFDA or Chinese ministry of health regarding the testing or regulatory status of this Chinese peramvir product. Based on responses to unofficial inquiries made to persons familiar with the industry, we believe this Chinese peramivir product is only in development and a long way from reaching commercial viability. Neither BioCryst nor NT Pharma has had direct contact with HNG Chembio Pharmacy or the Chinese Academy of Military Medical Sciences, so we cannot fully confirm the status of this potential competitor.
This is not a new story. We are focused on moving forward with NT Pharma in China, not worrying about possible competition when we have seen no clinical data on their product.
Rob Bennett
Executive Director, Business Development & Investor Relations
BioCryst Pharmaceuticals, Inc”
Bottom line: until they see any clinical evidence, they’re not even worried about this. It’s a non-event for them, and as Rob says, “This is not a new story.”
The end.
DR. JOHN PETERSON Reply:
November 16th, 2009 at 5:15 pm Comment # 12620
@LIONARY1, To respond to an unsubstantiated report only gives it credibility. Best to say nothing.
JOSEPHDED Reply:
November 16th, 2009 at 7:25 pm Comment # 12657
@LIONARY1, I WOULD NOT SAY A WORD ABOUT A PHANTOM DRUG WITH THE SAME NAME. WHEN THE DRUG ENTERS THE MARKET AND MORE IS KNOWN ABOUT THE TARGET MARKET, IT THEN BECOMES A MATERIAL EVENT. OTHERWISE KEEP MOUTH SHUT ABOUT DRUG.
Still nothing from BCRX on the Lazard conf? ..hmmmm
Jim Reply:
November 16th, 2009 at 3:18 pm Comment # 12578
@actionjack, According to the Schedule of Presenters BCRX is presenting from 5:10 to 5:35 on Tuesday, Nov. 17th.
http://www.lazardcap.com/conferenceList.aspx?tn=4&ln=2&itm=2123&lid=758
Click on “Presentng Company Schedule”
neil mac Reply:
November 16th, 2009 at 3:21 pm Comment # 12579
@Jim, I agree, usually I get an email days in advance and they put out a pr !!!
actionjack Reply:
November 16th, 2009 at 3:29 pm Comment # 12583
@neil mac, yep no PR yet, normally they would have announced it by now…
BCRX…all this idle speculation on material events, updating everyone, not doing the “PR they are supposed to” etc., chineese peramivir, etc…Relax, these are seasoned people running a publicly traded company that have more expertise in doing so than all of us (that’s why they are there and we are here ). The company has legal obligations/requirements, and has the interest of shareholders to account for. Let them do their job. Messages from Rob Bennett are nice, but he is a mouth piece and a filter, not a definitive source of information on a daily basis.
So instead of all of us getting frustrated on “why don’t they….”, how about a simple list of “looking forward to hearing an update on …..”…I am sure they will update when necessary/approprialte.
William Klawonn Reply:
November 16th, 2009 at 4:22 pm Comment # 12606
@Paul, Exactly: There is nothing in Reg SK (which givers what must be 8K’d and when) requiring a company to file an 8K when they obtain potential evidence of foreign competition. And certainly no company is going to put out a PR about such an event.
++
At the moment Biocryst dose not even have a possible patent infringement case in China, as the patent has been applied for but not yet granted. If and when the patent is granted, and the Chinese company then refuses to license, then Biocryst will likely file a patent infringement action (including seeking damages for any sales made by the infringer prior to the issuance of the patent). And even then, the filing of a legal action does not have to be 8K’d, but it would have to be blurbed in the litigation section of subsequent 10Q’s and 10K’s.
++
I really wish more investors would take the time to learn the basic rules governing the issuance of PR’s, the filing of 8K’s.
William Klawonn Reply:
November 16th, 2009 at 4:23 pm Comment # 12607
“governs” (not “givers”)
LIONARY1 Reply:
November 16th, 2009 at 6:52 pm Comment # 12647
@William Klawonn, re: your statement “I really wish more investors would take the time to learn the basic rules governing the issuance of PR’s, the filing of 8K’s,” your point is well taken, though not everybody here is an attorney like you. I just tried to educate myself quickly, but I can’t say that it was that simple. Yes, as you were saying, it looks like nothing on the Form SK requires disclosure of this kind of event, though I note that in Section 8, the Company has the “option” of disclosing any event which it deems important for investors.
http://www.sec.gov/about/forms/form8-k.pdf
That said, I note that in their just issued 10-Q, the Company stated: “We expect to encounter significant competition for any of the pharmaceutical products we plan to develop. Companies that complete clinical trials, obtain required regulatory approvals and commence commercial sales of their products before their competitors may achieve a significant competitive advantage. Such is the case with Eisai’s Targretin for CTCL and
the current neuraminidase inhibitors marketed by Glaxo Smith Kline and Roche for influenza. With respect to the neuraminidase inhibitors, these companies may develop i.v. formulations that could compete with peramivir . . . . If one or more of our competitors’ products or programs are successful, the market for our products may be reduced or eliminated.”
It seems to me that if the Company thought it important enough to mention that if i.v. versions of Tamiflu or Relenza are developed, it could have a detrimental effect on the Company, then it might be as significant (if not more significant) to have another company develop the very same “permavir”.
LIONARY1 Reply:
November 16th, 2009 at 6:56 pm Comment # 12650
@LIONARY1, my point being that maybe these news (if substantiated) should at least show up on the next 10-Q.
MR. BARRY H WHALEN Reply:
November 16th, 2009 at 5:09 pm Comment # 12615
@Paul, I couldn’t agree more. After reading the bios of all the Kleiner Perkins principals from the KPCB website, from Brook Byers on down, It’ pretty clear to me that we should stop acting like BCRX management just fell off the turnip truck. BCRX is in good hands and so is the stock that KPCB still owns.
DAVE G Reply:
November 16th, 2009 at 6:53 pm Comment # 12649
@Paul, Agree. However it would be prudent to keep an eye on the competition as usual. BioCryst will be doing that, no doubt.
tx for the update MM, on CRXX.
Avocado:
pay NO att’n to Dan. he is the PITA. God forbid U ask where the next order is for Peramivir. He’ll think u r complaining. I have him on IGNORE
avocadodrummer Reply:
November 16th, 2009 at 8:36 pm Comment # 12668
@joseph, Where IS the next order?
dan Reply:
November 16th, 2009 at 9:55 pm Comment # 12681
@joseph, i was willing to drop it!
Mrs. Bank and economy bear Meredith Whitney trying to hold back the markets today….
Meredith Whitney comment via cnbc alerts – fwiw – I have never been so bearish in over a year. We are due for a double dip recession. iphone cnbc real-time alert
—
But I am here and trust Mr. Murphy.
DAVE G Reply:
November 16th, 2009 at 9:04 pm Comment # 12670
@Todd, Meredith Whitney back to being negative on the banks, and she sees the $1.5 trillion reduction in consumer credit lines as being negative for the economy. Yup. That’s so last year, Meredith!
Chris: I noticed you and I got the same email WRT the 30k batch of Peramivir NOW being ready. In fact, I got the email last Friday, and the tone suggests that the batch has been ready for about a week now, dating back a week ago Monday. So, I ask MM et al: why haven’t we seen an additional order for peramivir? many here that stonehouse has orders on his desk, and have mentioned “rationing”. Until I see a PR, i don’t buy it. JMO
Marian Reply:
November 16th, 2009 at 4:20 pm Comment # 12604
@joseph, 100% agree; I’m with you on this one.
Chris Reply:
November 16th, 2009 at 6:14 pm Comment # 12637
@joseph, I was planning on selling some of my NOV ITM BCRX calls tomorrow if BCRX didn’t cancelthe hearing but I needed the cash today and took some profits. I still have some Nov ITM calls a(and, for me, mucho stock) and now plan to let them ride a bit. I look fwd to hearing what happens at the Lazard conf, but hope it cancels (smiley face)
Marian Reply:
November 16th, 2009 at 7:22 pm Comment # 12654
@Chris, I have only 100c for November and I’m not going to sell anything until after the conference tomorrow evening, or maybe not at all …
Most of contracts I have are for December ITM.
About shares I don’t worry at all.
IMO: keep the calls at least until Wednesday morning.
Chris Reply:
November 17th, 2009 at 7:05 am Comment # 12753
@Marian, BCRX offering 5 million share dilution. Guess I got while the gettin was good
Without giving away his newsletter comments for free, Thomas Calahandra has excellent bcrx comments in his newsletter just issued. http://www.tickertrax.com
I was wondering how long it would take…..
The mail is on YMB with this added bit at the end,
.
This is not a new story. We are focused on moving forward with NT Pharma in China, not worrying about possible competition when we have seen no clinical data on their product.
.
http://messages.finance.yahoo.com/Stocks_%28A_to_Z%29/Stocks_B/threadview?m=tm&bn=2024&tid=95076&mid=95076&tof=2&frt=2
William Klawonn Reply:
November 16th, 2009 at 4:25 pm Comment # 12608
@Jaime Ortega, when Bicryst’s patent application in China results in the issuance of a patent, this will sort itself out quickly I believe.
William Klawonn Reply:
November 16th, 2009 at 4:29 pm Comment # 12609
BTW, the guy who posted about the China issue on Yahoo is more than a bit naive if he s long BCRX. I am contantly amazed how longs can post food for the bashers. Not that the information isn’t important or material, but putting it on yahoo only provides ammo for the shorts and manipulators who will twist it.
I feel like we’re on a playground somewhere!
WK: I posted MY email from ROB at BCRX on IV. if someone copied and pasted it on YHOO, who cares. Wont hurt us IMO. If you go to IV and read my email, U will see that this china knock off is just that, a knock off.
joseph Reply:
November 16th, 2009 at 5:13 pm Comment # 12616
@joseph, WK: NT Pharma is their” partner”, or distributor in China, as announced by their PR in September:
NT Pharma is an experienced distributor in China with a sizable organization. We announced the deal with them Sept 15. More information at this link:
http://investor.shareholder.com/biocryst/releasedetail.cfm?ReleaseID=409198
NT Pharma was established in 1995 and has over 1,000 employees, corporate offices in Hong Kong and sales and marketing subsidiaries in Shanghai, Beijing, Guangzhou, Suzhou, Taizhou and Hainan for the distribution of pharmaceutical products including prescription medicine and vaccines. In 2009, the Group expects to achieve sales revenue of RMB 3 billion (U.S.$440 million), with a nationwide network that covers more than 100 cities, 1,500 hospitals and 12,000 points of vaccination, reaching over 90% of China’s urban population.
William Klawonn Reply:
November 16th, 2009 at 5:13 pm Comment # 12617
@joseph, Yes, I know it’s a knock off. But, still, news that a company is out there producing pirated copies of your product is not good news. My point was that the shorts and bashers will almost certainly seize this info and twist it into a negative for BCRX. I think that longs should carefully consider whether posting something on a public message board is in their own financial interest. We owe no duty to post the stuff we find or our analyses out there.
daniel Reply:
November 16th, 2009 at 5:20 pm Comment # 12623
@William Klawonn, when you post something here you should assume it will end up there.don’t fool yourself there are shorts amoungst us.
WK; it is OLD news. I sent this Chinese link to Rob MANY weeks ago. It has been circulating for a while. Their is PLENTY of good news in the email I got from Rob today.
William Klawonn Reply:
November 16th, 2009 at 5:17 pm Comment # 12621
@joseph, OLD news to you and me and a few others, maybe. But it is not OLD news to a lot of others.
bbildman Reply:
November 16th, 2009 at 5:43 pm Comment # 12631
@William Klawonn, First, I appreciate joseph’s efforts in contacting Biocryst about the China issue.
However that said, I also consider the China issue perhaps not one of concern to MANAGEMENT — but in the greater world inhabited by shorts who would LOVE to see this share price go down, I think it could have the prospect of ammunition for them.
Of greater concern to me, in agreeing with joseph, we had such great hoopla when the EUA and the order from the US government was announced. Anticipating more ROW orders, I had/have great expectations. BUT, nothing has come to pass…at least publicly, and if joseph’s IR reply is correct, Biocryst has the 30K sitting somewhere waiting to be delivered.
The silence is quite amazing, and I am ready to hear more from management other than an appearance at a conference. The current price will not hold if this continues too long — I know BCRX knows this.
Let the torpedoes go.
Okay so I am the cousin that nobody wants to come over for Thanksgiving because he is so negative and NEVER shuts up. That said, I am still not cozy with the BCRX explanation for what is happening in China and let me state why so that any and all can take a whack at “Congressman Dave, the Pinata”
1) So what if the Chinese drug is behind in testing; with the stroke of a pen it can be authorized for use. This is China not the US.
2) At the least we have lost China as a potential market.
3) At the worst BCRX has lost pricing power for the ROW orders because of the competition.
4) Why would the Chinese order half a billion dollars of drug from a US company when they can make their own.
5) Why would any other country pay a premium for Peramivir from BCRX as opposed to the Chinese drugmaker? All they have to do is say “it is the same molecule and it has proven to work” case closed in case of emergency or cash shortage.
I know there have been many cases of poor quality control on products shipped from China however, they executed those who broke the law so my guess is that compliance and quality are at least on a uptick.
Asking these questions is part of due diligence and the answers/explanations that have been proffered to date have fallen short of soothing my battered investment soul.
Whack away, we’ve got all day. Just please don’t hit me in my creamy nougat center.
CDG
William Klawonn Reply:
November 16th, 2009 at 5:26 pm Comment # 12625
Congressman: this is not a whack. Your comments make sense to me. They are, in fact, exactly the kind of comments that a Yahoo basher could make based on the Chinese prated peramivir story. My request, let’s keep this discussion in house.
MR. DAVE GLISSMEYER Reply:
November 16th, 2009 at 5:36 pm Comment # 12628
@William Klawonn, I am in TOTAL agreement with keeping this here, I rarely post on Yahoo. I would just like some answers that satisfy me. My lips and keyboard are sealed.
DG
Haut Reply:
November 16th, 2009 at 5:39 pm Comment # 12630
@MR. DAVE GLISSMEYER, First of all Dave, why should we assume that an authentic, effective version of Peramivir even exists in China. This could be some Chinese Short fund putting together a “Bioanalytics” type submission to cap the stock. I think you are assuming too much w/ regards to current status/viability of any Chinese offering that is not licensed from BCRX. In short, no product = no competition, no lost revenues, no price concessions, etc
MR. DAVE GLISSMEYER Reply:
November 16th, 2009 at 5:54 pm Comment # 12634
@Haut, OK Haut, point taken; score one for the good guys. What were the lyrics of that Buffalo Springfield song..”Paranoida runs deep, into your soul…..something something creep.”
My hope is that your hypothese is correct but I wonder, could this be one of the reasons why no ROW orders have shown up yet?
Cripes, just listen to me, I can see them now, hundrends of Chinese Pharma (or are they “metals holding company reps”) showing up at steel mills saying we have a new alloy that will make your steel more rust resistant and “Oh by the way, my home office just sent me a fax saying that we have this new anti-viral compound that you can inject via IV into your workers and keep them on the job; we will toss that in with an order today.”
Please whack me; hard.
CDG
Haut Reply:
November 16th, 2009 at 6:00 pm Comment # 12636
@MR. DAVE GLISSMEYER, no problem Dave i feel equally stressed. Sometimes i equate the feeling to having just pulled the slot machine handle and waiting for the reels to stop. Will there be a cherry or will there be 3 Genies?! LOL, our time will come, we just need a little more patience.
Jaime Ortega Reply:
November 16th, 2009 at 6:15 pm Comment # 12638
@MR. DAVE GLISSMEYER,
.
Yeah… sorry I couldn’t make it to your Thanksgiving the past few years… Busy with stuff, you know…?
.
Seriously now..
.
1) If this is a knockoff of P, there is no testing needed. If it’s not, the drug still needs to be effective or they have nothing.
2) True but govs. (even the Chinese gov) can’t sanction anything that is an obvious “theft” of IP. That is probably why somebody is claiming the “nationally developed from scratch with only chinese researchers, and resources. Even the syringes were chinese made, no question about that”. If this was the the Chinese gov talking I would see it as a covering of their tracks. So far nobody seems to know anything about this chinese P.
3) Again, depends on if what they have is a “generic” version of P or not. If it is, then the China market might be gone. If it’s not, then the new formula still needs to work and P will loose the worldwide exclusive on antivirals.
4)If the chinese gov decides to jump from the “no soup fouh you” bridge they wouldn’t. They just would deny the patent to Biocryst or give some other reason for validating their local brew.
I don’t think they would go that route though…
More likely, if it is a copy of P, and they don’t want to be sole sourced by a company of the West in this dire time, they would continue making their version of P. but order a few thousands for a cover-up. They can pretend that the flu never got there thanks to their outstanding efforts in combating the spread and that’s that.
If it is not a copy of P but their own “version” of antiviral, then there is really nothing anybody can do. It still needs to work though!
5) If it’s a copy of P, Biocryst has patents all over the world on the formula. Countries cannot officially buy from anybody else. There is no choice. What you might see though, is poor countries (with ties to China) buying the “generic” version under the table. Maybe if this happens, Biocryst will give special pricing to WHO for underdeveloped countries as an act of good will.
.
Regardless, BRCX still has ways to go even without China. When China didn’t want to pay for the DVD royalties, they made their own format. They didn’t just outright blow off the West.
.
-JO
MR. DAVE GLISSMEYER Reply:
November 16th, 2009 at 6:41 pm Comment # 12646
@Jaime Ortega, MORE GOOD STUFF. Look I may very well be making a molehill out of my sinkhole but the Q’s needed to be A’d and you presented them well.
Thanks for you thoughts, JO.
CDG
Don Reply:
November 16th, 2009 at 7:36 pm Comment # 12660
@Jaime Ortega, The Chinese steal our CDs and DVDs regularly along with our movies and software . Do you think it is above them to steal our antivirals? don
JOSEPHDED Reply:
November 16th, 2009 at 7:33 pm Comment # 12658
@MR. DAVE GLISSMEYER, I disagree with you. The Chinese would sell you and me a substandard drub, but not its own people. I think even if a chinese drug becomes available the chinese will not sole source the drug. Biocryst still will get a piece of the action in the worst case scenario. Only thing I am concerned about right now is the pace at which foreign countries as buying Peramivir. I have no doubt they will, but perhaps at a slower pace an/or smaller quantity than us shareholders would want. This is the only danger I see here.
LIONARY1 Reply:
November 16th, 2009 at 7:48 pm Comment # 12662
@JOSEPHDED, this has been my main concern as well. For example, Israel declared about a total of 40 H1N1 deaths from Apr thru Nov (presumably at an accelerating pace). So as long as their ICUs are not swamped, what is to stop them (at first) from just ordering 80 doses let’s say, for the next 80 patients who do do not respond to Tamiflu and Relenza and are critical? Same for ROW, I think the death numbers are proportionally similar in Europe.
On the other hand, BCRX said that they are preparing 130,000 courses of treatment, so they must see something coming down the pike.
@William Klawonn, I mentioned China/ peramivir on 9-20 on IV, post 1278. i am sure YHOO peeps saw it. Moving on.
Yeh well I feel like I’m bein’ “played with” about now. Ready for somebody to SXXT or git off the POT!!
Docs and Dentists tomorry so can’t watch good ol’ BCRX! Yu guys keep a eye out now , y’here!
Oh yeh, I remember ME saying “Patience is a virtue!”
Fuller
Mr. Murphy any thoughts on the general market….does it appear the S&P is on it’s way to 1160?
Michael Murphy Reply:
November 16th, 2009 at 6:38 pm Comment # 12645
@actionjack, looks like the low on Day 86 (Tuesday) was retested for some reason on Day 2 of the new cycle (end of day Thursday), probably because the short-term fractal dimension was so stretched. That was the real low, at 1085, and today the energy let loose to the upside. I will put out a Flash Alert tonight.
actionjack Reply:
November 16th, 2009 at 7:18 pm Comment # 12652
@Michael Murphy, thanks as always…great insight…
actionjack Reply:
November 16th, 2009 at 7:34 pm Comment # 12659
@Michael Murphy, Also what your opinion on Meredith Whitney. IMO she was once right about being a bear on the banks, but has been completely off this recovery so far (really all of 2009). Now she comes out again today and touts a double dip, which I dont believe for a second. Any thoughts on her market sense and or motivation…
Michael Murphy Reply:
November 17th, 2009 at 1:13 am Comment # 12714
@actionjack, I think she is very good-looking, and has made a lot of money being negative.
Michael Murphy Reply:
November 17th, 2009 at 1:12 am Comment # 12713
@Michael Murphy, flash alert is out
This came to me today from Paul Goodwin (Cabot Emerging Markets, #1 HFD Advisory after NWI):
++
“Re: HNG Chembio Pharmacy Ltd, Xiamen, PRC. I did my due diligence and turned up Chembio Diagnostics (CEMI), which trades on the bulletin board. The stock is about as volatile as you would expect with a 30-cent stock, but the trend is clearly up. I still can’t get a lot of information about products, and I’m not reassured by having Hunan Nonferrous Metal Holding Group as a parent company.
++
“Again, let me know if you get more details.”
++
Any additional details for Paul? Other than the coincidence of “Chembio,” why did his due diligence turn up this company?
I hope Stoney puts out some good poop tomorrow so some of you can take a chill pill!
actionjack Reply:
November 16th, 2009 at 7:24 pm Comment # 12655
@ROBERT RAYL, I agree RR, news can come tomorrow or by the end of the month, but it is coming. These negotiations take time, i think there is a little paralysis by analysis by shareholders on BCRX. It’s just of matter of when.
MR. DAVE GLISSMEYER Reply:
November 16th, 2009 at 7:24 pm Comment # 12656
@ROBERT RAYL, me too amigo.
SLV was up 5% today to $18. 2X 3m avg vol.
It has recently been lagging gold. Looks good now for move to $20.
The Chinese steal our CDs and DVDs regularly along with our movies and software . Do you think it is above them to steal our antivirals? don
Ralph Reply:
November 16th, 2009 at 8:12 pm Comment # 12667
@Don,
Pirating CDs and DVDs is a long way from copying antivirals from a technology perspective, but even if the Chinese would do that for the masses, you can bet that the senior government officials will be getting the good stuff (meaning supplied by Biocryst via NT Pharma).
So, I think BCRX should get a decent revenue stream from China in any case.
Just got this email verbatim from Rob Bennett:
Joseph,
We are scheduled to present at 5:10PM ET tomorrow at the Lazard conference.
Rob Bennett
Executive Director, Business Development & Investor Relations
BioCryst Pharmaceuticals, Inc
4505 Emperor Bv, Suite 200
Durham, NC 27703
JOSEPHDED Reply:
November 16th, 2009 at 8:01 pm Comment # 12664
@JOSEPHDED, I told him I was rearranging my schedule to attend. He promptly responded with the above.
dogdayaftern00nTM@gmail.com Reply:
November 16th, 2009 at 8:01 pm Comment # 12665
@JOSEPHDED, Can someone ask him why they haven’t released a PR for this and if they are going to have a webcast?
JOSEPHDED Reply:
November 16th, 2009 at 8:03 pm Comment # 12666
@dogdayaftern00nTM@gmail.com, I sent him the two questions in response.
There is far too much credit given to Yahoo message boards. Those boards are a joke.
JOSEPHDED Reply:
November 16th, 2009 at 9:26 pm Comment # 12673
@Patrick Spezio, I totally agree with you. It’s the publishers or advisory publications advocating the interests of shortsellers that is material. Yahoo is irrelevant.
JOSEPHDED Reply:
November 16th, 2009 at 9:32 pm Comment # 12677
@JOSEPHDED, its a pissing matching on the Yahoo Board.
Korea. mentions tamiflu and anti-viral vaccines??? Tey have called peramivir a vaccine before.
In fear of the fast-spreading virus, the government has provided the Gaeseong site with anti-viral vaccines, enough for about 50 people, and secured a small amount of Tamiflu to treat about 100 people, ministry officials said.
http://www.koreatimes.co.kr/www/news/nation/2009/11/113_55592.html
Can we listen via a web cast tomorrow?
JOSEPHDED Reply:
November 16th, 2009 at 9:27 pm Comment # 12674
@ROBERT RAYL, no response from IR yet. I don’t know if he will respond to that question. If he does I will post it.
JOSEPHDED Reply:
November 16th, 2009 at 9:29 pm Comment # 12675
@JOSEPHDED, I get the sense BCRX is playing the conference by ear and they seem to be hoping to be able to announce something by tomorrow afternoon. Maybe they are working on some orders which may close tomorrow. If they don’t my guess is they don’t attend the conference tomorrow. They just give me the impression they are trying to play safe.
JOSEPHDED Reply:
November 16th, 2009 at 9:31 pm Comment # 12676
@JOSEPHDED, I know Bennett is on the road and he will not be in the NC office until Friday. I don’t know why. BCRX operator told me this.
Haut Reply:
November 16th, 2009 at 9:36 pm Comment # 12678
@JOSEPHDED, why not announce without conf presence? dont understand why participation in conf is necessary?
JOSEPHDED Reply:
November 16th, 2009 at 11:28 pm Comment # 12693
@ haut, if I were BCRX and wanted to make the shorts sh*t their pants I would do things in unexpected ways. I know they are fully aware of 10.3 shares have been shorted because I emailed them 10 days ago and suggested they devise an antiviral for shorts. If I were the CEO, I would do things unconventionally to accomplish this task of starting the catalyst to higher share price. Lets hope they know what they are doing. GLTA.
rodney beasley Reply:
November 16th, 2009 at 11:45 pm Comment # 12701
@JOSEPHDED,Now you are thinking like I am,,,I think BCRX mgmnt team wants to choke the shorts,that are well aware of the biologic reports and other we ALL know,Rob did his research on biologic,he knows about the street crap,,they all know they can hold out and wait for the perfect storm PR that could send us upward,i think thats why we are not getting thses crappy lil PRs on the 10 courses or whatever the number,I sent them email telling them I appreciate them for not cramming a bunch of trivial PRs,,thats what i lie about the NEW seasoned BCRX mgmnt,,these guys are the real deal,Rob in IR,and on up the food changed are from bigtime firms,,,they know what they are doing,,that why i am dying to put more into this,,Does anyone here have the stuff to buy more here?to me if you are not willing to buy here you may be in the wrong stock,thats whats make a strong stock good is strong holders,i wouldnt mind a one more rinse and wassh cycle if we get no news this weeek,I would be buying there,,or maybe buy if it starts hitting recent highs,,1999,2000,2201 show stock over 30,,so why can we not go there again,we are in a much better cash burn rate,cash on hand,,Hell everything is better now than then,,,ok so we have to think about the market then,,lotsa stuff overvalued then i guess,,but with that in mind,,,why could we not see 20.00 short term??Someone throw me something here,what the hell am I missing??
bobglyc Reply:
November 17th, 2009 at 2:07 am Comment # 12725
@JOSEPHDED, you know, it’s a strong possibility that they may have been and are working on a merger agreement with a larger pharmacutical company. That would follow such a news “quiet period” that they have gone through, considering. Strong government backing through BARDA, which would make FDA approval all the more likely, very highly priced drug, high likihood of strong demand, and a good upcoming pipeline. Who knows? But could be.
Bob
I get the sense BCRX is announcing VERY BIG news tomorrow!
Haut Reply:
November 16th, 2009 at 9:52 pm Comment # 12680
@ROBERT RAYL, hope you’re correct. please enlighten me. TIA
Todd Reply:
November 16th, 2009 at 9:58 pm Comment # 12682
@ROBERT RAYL, Robert – is your hunch based on hope, facts, or both? I like the idea either way.
You post so many facts, I’m thinking that maybe you think we are due.
“I get the sense BCRX is announcing VERY BIG news tomorrow!”
bobglyc Reply:
November 17th, 2009 at 2:12 am Comment # 12726
@ROBERT RAYL,
@JOSEPHDED, you know, it’s a strong possibility that they may have been and are working on a merger agreement with a larger pharmacutical company. That would follow such a news “quiet period” that they have gone through, considering. Strong government backing through BARDA, which would make FDA approval all the more likely, very highly priced drug, high likihood of strong demand, and a good upcoming pipeline. Who knows? But could be.
Bob
DR. JOHN PETERSON Reply:
November 17th, 2009 at 2:35 am Comment # 12729
@bobglyc, If they are working on a merger, I hope the drive the hard bargan they did with the government. Because of Nov options I would like to see them finish by the middle of this week. GSK? Maybe it will be a US marketing agreement. That should be worth a lot to GSK with the resistance developing to Tamiflu.
bobglyc Reply:
November 17th, 2009 at 2:49 am Comment # 12730
@DR. JOHN PETERSON, I hope so too. Naturally it’s just a guess on my part, but I wonder….This stock really looks to have huge potential, and we all can agree their mgt. is top notch. They got an excellent price to work with, so why not…not a huge amount of outstanding shares. Maybe the stars have lined up??
@Michael Murphy,
++
re: How to alert subscribers to your “Flash Alerts?”
++
Is it possible (practicable) to be sent a brief cell phone message, announcing a “flash alert” and “time” of issue? A cell phone is suggested for obvious reasons: Most have one; it’s affordable to acquire; it enables immediacy to your timely notice wherever we may be; if unavailable we can be left a message, expected to phone a predesignated # for a recorded message of your flash, or to get to a computer.
++
Today’s timely/valuable CRXX Flash Alert prompted my airing a suggested solution, but mostly to identify a
subscriber need. Just recently, as a PST retiree with other commitments, I enjoyed keeping online for BCRX’recent volatile period, got up early for premarket and late with our valuable Comments section, monitoring for your great inputs. For a lot of reasons, I expect few of us can sustain this constant online attention. My cell phone suggestion is just that, an attemptat better connectivity with balance. Perhaps you/your IT can come up with a feasible mechanism. I don’t expect this will nexus for nothing, but any reasonable premium is worth consideration.
++
Thanks again for YOUR TIRELESS AND OUTSTANDING GUIDANCE, Michael!! YOU ARE THE BEST even if in CO and not Half Moon Baying!!
++
Thanks for your reply and the thoughts of any fellow subscribers.
Mike Lum Reply:
November 16th, 2009 at 10:15 pm Comment # 12684
@ARDENTRC, The text messages sent directly to my cell phone work perfectly. They provide everything I need to respond immediately. They are quicker than an actual voice message because they don’t require accessing a voice mail system to know what is going on. Just my 2 cents.
Michael Murphy Reply:
November 17th, 2009 at 1:18 am Comment # 12715
@Mike Lum, Mike – are you getting the txet message from email, RSS feed or Twitter?
Mike Lum Reply:
November 17th, 2009 at 3:30 am Comment # 12733
@Michael Murphy, I never get emails notifying me of alerts. I signed up for to be notified via Twitter but when I get the text messages, they don’t look any different than any other test message I get on my iPhone. I thought everyone was getting them but I guess not. I works perfectly. I even provides a link directly to the site.
ARDENTRC Reply:
November 17th, 2009 at 3:55 am Comment # 12735
@Mike Lum, Thanks for offering to help!! (I also see that MM’s reply to you was: “-are you getting the text message from email, RSS feed or Twitter?”)
++
Are the text messages you receive a brief highlight of MM’s actual Flash Alert? (Can’t imagine you’d get the entire Alert.) I assume I can just contact MM’s Customer Service to sign-up for Flash Alerts texting.
++
I’m puzzled by MM’s question to you, but figure he’ll get to me if needed.
++
Thanks again, Mike!
Van Reply:
November 17th, 2009 at 3:23 am Comment # 12732
@ARDENTRC, All cell phones have an e-mail address that will allow you to receive a text message.
For instance
Verizon is simply [10-digit phone number]@vtext.com,
TMobile [10-digit phone number]@tmomail.net,
and AT&T [10-digit phone number]@txt.att.net.
You can set your e-mail on this site to that address and it will show up on your cell phone as a text message. I hope this helps.
Mike Lum Reply:
November 17th, 2009 at 9:48 am Comment # 12845
@Van, That must be what I did. I have ATT and the notification rings my phone. On the screen, I see a short note that says that their is a flash alert of whatever with a very brief description. I can open the test message that links directly to the NWI site. Great feature!
@William Klawonn your post at 5:26 pm and daniel your post at 5:20 is my POINT.
this is the problem. anyone who doesn’t understand this is doing all of us a great disservice.when questions are pubilicly raised that could put doubt in “weak” holders hands,of course its going to be used by the other side.ppl that do that are either naaive or have other motivations.the most effective “bashers” are the ones who pretend to be long first then find a reason to sell and then announce they have sold (usually on a down day)thats part of the game.call it a “wolf in sheeps clothing”.when i have questions ,i call, email and try to find the answers anyway i can without airing doubts/questions publicly. but go ahead keep it up.tell me to stfu when someone starts this crap. truth is if murph can pull my posts whenever he wants.
daniel Reply:
November 16th, 2009 at 10:33 pm Comment # 12686
@dan, wish i could buy the shorts playbook for 350 bucks.
rodney beasley Reply:
November 16th, 2009 at 10:57 pm Comment # 12687
@dan, Paranoia will destroy you,cmon guys i thought this place was to bounce ideas etc,,i dont want to just hear one side comments,bla bla,,truth is we need the shorts,you have to have them ,I say let em short,the more the merrier.
I ame a psot the other day wanting advise on putting another 100k in this stock,like bracket buying,that basically what I have been doing all the way up,,
I would like to hear some technical guys views on what stock will do if it punches thru prev high of 13 area,I think if it makes it thru there it could easily go to 15-17 short term,does anyone have a view on this??I would like to discuss this if anyone wants to,or is that off topic too much?I really want to put another 100k,I need some solid advice guys,,lets quit bitching and make some money,,,lotsa smart peeps here,,we should put our collective effort into looking at all sides of the trade,investment,,sequential etc..there are many ways to skin a cat(sorry PETA folks)Do any others here do the bracket buying as I?or am I the only one stupid enough to practice this outdated strategy??
When i go back thru my best postions of my life,this is how I made the most money,,I have made nickels and dimes trading,I love trading swings and daily mo mo stocks,been trading WLT lately,,its been so easy as of late,,but now that I wrote this i will never make money on it again,lol
I would love to see chat about that kinda stuff,I have found when you surround yourself with smart people,you are more likely to succeed,,but I really dont like sheep menatality.I love this site,I wished we had a daytrading area as well,I feel like we could make some cash.
JOSEPHDED Reply:
November 16th, 2009 at 11:10 pm Comment # 12688
@rodney beasley, you are correct. We need the shorts to help drive the stock higher in a new york minute. There would not be much fun. Lets face it, most shorts are already in the stock and the downside volitility should be minimal. I see more upside presure because the shorts 10.3 million of them must cover at some point in time. Hopefully sooner rather than later.
avocadodrummer Reply:
November 16th, 2009 at 11:17 pm Comment # 12689
@dan,
Dan, while I understand your viewpoint, the problem is that taking the approach you suggest will, in fact, result in this board becoming an echo chamber where only positive aspects of a stock are discussed. Since most people here presumably put more faith in the MM board than a Yahoo board, we end up with a situation where people may be dismissing, or completely unaware of, risks to their investments.
*****
How would you have critical views disseminated?
*****
The very nature of information is that it can used for manipulative purposes as well as informative purposes. However, that is all the more true in an information vacuum. This is precisely the tactic used by the former Soviet Bloc and most other totalitarian regimes. The shorts will use whatever information they can to put fear in the heads of weak holders. If the information they put out, and the spin they put out, has not been openly discussed, it is more likely to be believed. You can call me naïve, but I firmly believe that maximum free flow of information is by far the best means of . . . well, doing just about everything from picking stocks to picking spouses to picking politicians. The result is far from perfect, but it’s better than the alternative as far as I can tell.
*****
As a matter of course, I do not take negative information, or even much positive information, that I come across here, and repost it on the yahoo board. That is because I don’t want to breach the etiquette here and also because we are all paying for good intel, so turning around and broadcasting it defeats the purpose of paying for the service. But if we cannot openly discuss our views here, then what are we left with?
dan Reply:
November 16th, 2009 at 11:32 pm Comment # 12695
@avocadodrummer, you miss the point. this is not a secure enviornment.all it takes is a credit card and lately it doesn’t even take that.
if you have intel to add i want to hear it. if i have intel i post it.btw china aint got nuttin.when the chinese orders are released some ppl are gonna feel pretty dumb.
avocadodrummer Reply:
November 17th, 2009 at 12:44 am Comment # 12706
@dan, No, I haven’t missed that pioint. My entire argument begins with the presumption that this is not a secure environment.
DinoHowl Reply:
November 16th, 2009 at 11:37 pm Comment # 12698
@avocadodrummer, Well said. I am interested in honest discussion of issues on this board not some paranoid filtered spin. It’s difficult to control where it goes, but if you stay current, you see it first here, and with more insight then when leaked elsewhere.
MR. LOUIS R PALEY Reply:
November 17th, 2009 at 12:27 am Comment # 12704
@DinoHowl, I have NEVER spent so much time on an investment site before. I spend the time here because it is clear that we can count on getting the latest news AND OPINION here, and that most participants are REAL investors, and a few are virtually genius sleuths, particularly using the web so effectively. So let us all be a little more respectful of each other, and STOP the personalization of the criticism. Such behaviour is just childish and wastes everyone’s time and effort. As far as I am concerned, positive AND negative opinions, if presented constructively, are perfectly fine. While MM has most of the facts to present to us, many of you have provided critical insight and viewpoints from various perspectives. That is all to the good.
Keep the good stuff rolling in; and keep the faith!
Louis
I see this endless bickering about China and Peramivir trihydrate…Adding three molecules of water to an existing molecule, doesn’t make a new molecule, many molecules can be purchase unhydrous or hydrated … so patent protection applies…now, we all know how China tends to ignore patent laws, and if true that this trial exists, there will be competition in China and all the other countries that can’t afford $3,000/ course. It will not be competition anywhere else in developed world, where rules and laws are followed…
On the other note, someone is seriously short and they are playing with Dec $2.50 calls again today, with over $5,000 in volume, flipping shares / in the money calls back and fort…I’m wondering if this should be reported to SEC?
I’ve had it with all this talk…I can’t take the pressure…I am going long BCRX on Tuesday…
Paul Reply:
November 16th, 2009 at 11:32 pm Comment # 12694
@Paul, Robert…I am afraid you are going to have to come clean also……
Paul Reply:
November 16th, 2009 at 11:33 pm Comment # 12696
@Paul, This is the confessional folks…come clean…
dan Reply:
November 16th, 2009 at 11:40 pm Comment # 12699
@Paul, i knew it!! lol ( had to add lol so nobody thought i really meant it)
Paul Reply:
November 16th, 2009 at 11:44 pm Comment # 12700
@dan, you too..after all this ! Could be most of this board is short and the longs are on yahoo ?
Ms. C? Jack from the Yahoo message board is trying to get in touch with Michael. Do you know how he can do this? Thanks.
doncl316 Reply:
November 16th, 2009 at 11:34 pm Comment # 12697
@MR. JAMES BARTON,
NewWorldInvestor@gmail.com
ms_chemeng Reply:
November 16th, 2009 at 11:48 pm Comment # 12702
@MR. JAMES BARTON, I replied…
MM, Jack is one of the longest longs on BCRX YAHOO board… big AVII long as well…
MM, NABI is a stock I have had a small and losing position on for several years but today they announced a world wide licensing agreement with GSK that could generate up to $10.00 per share in milestone payments and double digit royalties. The product is a nicotine vaccine which has completed phase 2 testing and will soon start the first of 2 phase 3 trials. Obviously, GSK is impressed with the data so far. What do you think of this stock and its potential? They bounced up 26% today so this is probably not the best time to buy but as the news fades I expect it will drop down. Would this be worth averaging down or placing on the buy list? I would appreciate your thoughts.
Re: BCRX. In reading the latest posts regarding Athena’s condition on YHB, a poster advised her father John of the following information.
Both tamiflu and IV Peramivir have been shown to be resistant to the H1N1 mutation of H275Y which is becoming widespread around the world. At the very least get the doctors to check that this mutaion is not present. See Q21
”The influenza A H1N1 clinical isolates
expressing the Tamiflu resistance-associated substitution H275Y appear to be resistant to Peramivir IV.”
http://www.cdc.gov/h1n1flu/EUA/pdf/peram...
I had not read this anywhere before…thoughts?
DR. JOHN PETERSON Reply:
November 17th, 2009 at 1:22 am Comment # 12717
@Mike Lum, I have seen this mutation mentioned in some of the articles on this board. I have been concerned that she may have relapsed because she was only given 5 days of Peramivir. Her test on 10/25 for H1N1 was negative. Did it stay that way?
William Klawonn Reply:
November 17th, 2009 at 4:59 am Comment # 12740
@DR. JOHN PETERSON, I understand that the tests often give false negatives. Her doctors should have known this and not stopped peramivir after five days.
DR. JOHN PETERSON Reply:
November 17th, 2009 at 1:24 am Comment # 12720
@Mike Lum, I have not seen that this mutation causes the virus to be resistant to Peramivir.
Michael Murphy Reply:
November 17th, 2009 at 1:26 am Comment # 12721
@Mike Lum, this was one guy and one test. I have also read that peramivir is effective against Tamiflu-resistant seasonal flu. It is an important issue, but I don’t think it’s really been tested yet. I did wonder if the failure of the South American intramuscular injection trail might have been because they were treating mostly Tamiflu-resistant seasonal flu, but BioCryst thought that was not the problem.
DR. JOHN PETERSON Reply:
November 17th, 2009 at 2:20 am Comment # 12727
@Mike Lum, The latest post on Athena is that she has once again tested positive for Influenza A. The typing is pending. She has been started on Tamiflu and Peramivir has been ordered. It will be interesting to see how long it takes to arrive with the new system.
November 2002
“Today’s Chemists at Work” Article
Adam Feuerstein, a stock analyst for
The Street (www.thestreet.com) who had
planned to report on the meeting, was
suspected of leaking information in the abstracts before they were cleared for public release, and ASCO withdrew his press credentials (7). Feuerstein accused ASCO of selectively distributing financially relevant information, a violation of the spir- it, if not the letter of Reg FD. (Reg FD does not apply to nonprofit organizations such as ASCO.)
(7) Abate, Tom. Cancer therapies at border where medicine, stock market collide. San Francisco Gate, April 22, 2002; http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2002/04/22/
BU17390.DTL.
Todd Reply:
November 17th, 2009 at 12:48 am Comment # 12708
@Todd,
http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2002/04/22/
BU17390.DTL
—
One last point: For the second straight year, ASCO has revoked the press credentials of a reporter in the San Francisco office of TheStreet.com, because the reporter, Adam Feuerstein, used data from ASCO abstracts in his biotech stock column.
If Feuerstein had been granted access to the abstracts on the condition that he respect the embargo, ASCO would be justified in saying he isn’t welcome to cover the event.
But that isn’t what happened. Analysts at US Bancorp Piper Jaffray, Deutsche Bank and Robertson Stephens cited the ASCO abstracts in reports to their institutional clients. Feuerstein cited these analyst reports in his articles.
If ASCO wants to crack down, it should go after the members who leak the reports, or the investment banks that circulate them, and not a financial reporter trying to let retail investors in on the secret.
Read more: http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2002/04/22/BU17390.DTL#ixzz0X5pJSlQ9
Watching the H1N1 flu pandemic
When you watch this you realize the world wide impact of H1N1 and the huge WW need for a real viable life-saving solution immediately – Peramivir
http://www.boston.com/bigpicture/2009/11/watching_the_h1n1_flu_pandemic.html
There is a new Flash Alert out on the market outlook.
MM .. FYI – I just got this page in my email alerts about an 30 mins ago. Just thought you might want to know.
Jack Hemmer Reply:
November 17th, 2009 at 1:23 am Comment # 12718
@Jack Hemmer,
MM or Ms Ca_Ching
Take a close look at this page.. let me know if you see anything peculiar. ;/
JH
Jack Hemmer Reply:
November 17th, 2009 at 1:23 am Comment # 12719
@Jack Hemmer, http://www.gbipharma.com/cpbheadlinefree.asp?newsid=2010111
Battling back from H1N1
http://www.omaha.com/article/20091117/NEWS01/711179942
I wish they would give peramivir much sooner!
State H1N1 death toll rises
3 more fatalities reported since April to 42; officials urge diabetes patients to get vaccine
Kim Kozlowski / The Detroit News.
http://www.detnews.com/article/20091117/LIFESTYLE03/911170332/1040/rss34
Another 3 H1N1 deaths reported in Iowa
http://www.postbulletin.com/newsmanager/templates/localnews_story.asp?z=2&a=425614
Tucson Region
Pima County’s H1N1 death toll rises to nine
http://www.azstarnet.com/metro/317869
During the day on Nov. 5, she went to Greenville Regional Hospital. Doctors told her she didn’t have H1N1, but she was given Tamiflu anyway. She couldn’t take it because she was vomiting.
http://www.individual.com/story.php?story=110252683
BIRMINGHAM, Ala., Nov 17, 2009 /PRNewswire-FirstCall via COMTEX News Network/ — BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) today announced that it is offering to sell, subject to market and other conditions, 5,000,000 shares of its common stock pursuant to an effective shelf registration statement in an underwritten public offering. BioCryst also intends to grant the underwriters a 30-day option to purchase up to an aggregate of 750,000 additional shares of common stock to cover over-allotments, if any. All of the shares in the offering are to be sold by BioCryst. Morgan Stanley will be acting as the sole book-runner for the offering, with JMP Securities and Oppenheimer & Co. acting as co-managers.
MR. DAVE GLISSMEYER Reply:
November 17th, 2009 at 8:16 am Comment # 12770
@Chris, geez louise…unbelieveable.
Dog: neuro was right; thanks god it is only 5mil and not 70.
Feeling bad …
upright piano…
Hello
I bookmarked this site. Thanks heaps for this!… if anyone else has anything, it would be much appreciated. Great website Super Pianoforte Links http://www.en.Grand-Pianos.org Enjoy!…