The Fed stood pat yesterday, as was widely anticipated, yet the market reacted with another breakout. And over the past week, the S&P 500 has taken out two crucial levels, first 1365, which was the breakdown level in January 2001 that signaled the worst down-leg of that bear market, and then 1377. It is showing tremendous strength and is now in a position to sail up to 1405 or even 1440. I think you can count on a pullback or retest of 1365 from those levels, or even 1325. But if the market survives that retest, it will be all-clear to go to new record highs in 2007, possibly above the March 24, 2000, peak of 1553.
With all of this recent market activity, I must admit that I’ve been wrong in expecting a September/October market decline to let us get back into the market gracefully. Why was I wrong? Well, I think the problem lies with the record level of short interest. Too many people were either hedging or betting on a decline, so every little sell-off stopped right at the prior breakout level, and then when the market started to bounce another group of short-sellers rushed to cover their positions. The result is a parabolic ascent since Labor Day.
The trouble with parabolic ascents is that they always break, and usually result in parabolic declines. However, you never know how far a blow-off move can go. So, I think it is safe to put a third to a half of your cash position to work now, but only in stocks that have very little downside risk even if the market started to correct tomorrow. That would be stocks like BioCryst (BCRX), Dendreon (DNDN), eResearch (ERES), Harmonic (HLIT), Zhone (ZHNE), Omniture (OMTR), Connacher Oil & Gas (T.CLL), Gasco Energy (GSX), Infinity Resources (IFNY), Rentech (RTK) and Alvarion (ALVR). Today, I am going to make those 11 stocks the new Top Buy list, because they could benefit in a market that could move sharply either way. I’m also leaving Telkonet (TKO) on the Top Buy list.
In addition, I am making a new recommendation today — actually a re-recommendation of a stock that we’ve made good money with in the past. The stock took a big jump today, and the buy limit that I was planning to implement was $1.50 above the market price and now it’s $3.00 below. But when this parabolic move breaks, you should be able to buy the stock beneath my buy limit.
Personalized Cancer Treatments
You know that I like Dendreon because they will have the first FDA-approved personalized cancer treatment with Provenge for prostate cancer. Provenge is personalized because it is made from an individual’s cancer cells. The oncologist removes cells from the patient’s tumor and sends them to Dendreon; Dendreon then amplifies (grows) the cells, attaches an antigen, and sends Provenge back to the oncologist to be re-infused in the patient.
Now, while Dendreon’s personalized cancer treatment process is already familiar to most of you, there is another, broader kind of personalized treatment based on looking at the genetic structure of the tumor. That’s what today’s recommendation is based on.
In my book, Every Investor’s Guide to High-tech Stocks and Mutual Funds, I told the story of the New York lawyer with brain cancer who paid to have his tumor’s genes sequenced. It turned out to be metastasized breast cancer, even though he didn’t have any obvious tumors in his chest, and even though men only rarely get breast cancer. Once the oncologist knew exactly what kind of cancer the man had, he treated the lawyer with Herceptin, and the cancer went into remission.
It cost $100,000 that the lawyer gladly paid for the treatment, and my point in the book was that the cost of that test would fall every year, and eventually an event would occur to make gene sequencing a standard diagnostic test.
That event just happened.
In the new issue of Nature Medicine, researchers from Duke University said that they have a genetic test that is 80% accurate in predicting which drugs will be most effective against a particular cancer, given the patient’s genetic make-up. This test can predict whether a single drug or a specific combination of drugs will work.
So, how does this genetic test work? A gene chip is used to scan the messenger RNA (ribonucleic acid, or mRNA) from thousands of genes in a tumor. Messenger RNA translates a gene’s DNA code into the proteins that run a cell’s functions, so mRNA can be used as an indication of how active any particular gene is inside the cell.
This research was performed on tumor samples from several hundred people with ovarian, breast and lung cancers, and leukemia. Duke researchers will start testing the genetic assay in breast cancer patients next year.
Over 400,000 people in the U.S. alone are treated with chemotherapy every year. Yet, in a famous survey of 64 oncologists at the McGill Cancer Center in Montreal, 58 of them — more than 90% — said that if they or their family members had cancer, there was no chemotherapy program that they would undergo. They said that all chemotherapy programs are ineffective and have an unacceptable level of toxicity. A similar survey by the Los Angles Times found that 75% of the oncologists surveyed considered chemotherapy and radiation as unacceptable treatments for themselves and their families.
These oncologists only prescribe these treatments for their patients because it is the standard of care. They would not take it themselves because they know chemotherapy is miserably difficult, destroys the immune system, and there is no firm basis on which to select a drug.
Gene assays should let oncologists personalize chemotherapy for better outcomes by identifying the right drug or drugs for each individual patient. This will work on the new targeted biotech drugs like Tarceva and Herceptin, which target certain genetic subsets. And it should also work on the typical drugs used in a standard practice, such as cisplatin, paclitaxel, topotecan and 5-fluorouracil.
So, here is the trigger: Doctors need this information to select the right chemotherapy drugs for each patient, and choosing the right drugs will dramatically improve outcomes. The Duke researchers found that comparing their genetic assay predictions to the actual results patients had with chemotherapy showed that the tests are 80% accurate in predicting whose tumors would be stopped by a particular drug or combination of drugs. Genomic tests are going to revolutionize cancer care, and the payers — the HMOs and Medicare — are going to have to foot the bill.
Special AFFX
The basis of the tests at Duke was a “gene chip” made by today’s buy recommendation, Affymetrix (AFFX). Gene chips are made in a semiconductor-like process, putting layer after layer of the As, Gs, Cs and Ts that make up a strand of DNA onto a glass substrate. The result is a microarray of tiny strands of DNA called oligonucleotides, packed vertically on the chip. Affymetrix knows the makeup and location of every strand, so the chip can be used to detect the presence of a sequence in a sample.
Here’s how that works. The As, Gs, Cs and Ts (and Us, in messenger RNA) make up the double helix of DNA and are very attracted to their complements. An A will try to bind with a T (or a U, for mRNA) and a G will try to bind with a C. Suppose Affymetrix creates a very short oligonucleotide by depositing first an A, then in the second layer a G, then in the third layer another G, and then in the fourth layer a T. That sequence — AGGT — will try to bind with its complementary strand, TCCA, from a tissue sample. So, the AGGT acts as a probe to determine if TCCA is present, and if it is, it can be made to glow.
Affymetrix can pack a quarter million probes on a chip, up from the few thousand that was possible five years ago. They can now put the human genome on two chips. They run a sample across the chip to see what glows. For example, suppose the bird flu mutates into a virus that can cause a pandemic. By exposing the virus to a chip, researchers can see what gene sequences are present and how that differs from the unmutated virus. Then they can zero in on the mutation, and develop an antiviral and a vaccine that will be effective against the changes. Or in the case of different cancers, they can run a cancer cell across the chip, and identify what type of cancer it is.
Affymetrix owns most of the intellectual property in this area. Some companies provide complementary DNA (cDNA) probes — a relatively low-tech solution that has a small market share. Agilent has less than 10% of the market, focused in the low-density area. Motorola and Corning tried to compete in high-density gene chips, but couldn’t get around the Affymetrix patents.
Affymetrix grew very rapidly in the late 1990s, approximately doubling revenues every year through 2001, to the $225 million level. Their growth slowed in 2002, when they hit $290 million, and practically stopped in 2003 at $301 million. Although 2004 was up 15% to $346 million, 2005 was a real disappointment at $368 million. AFFX had problems turning out enough of the new, very high-density chips. They started missing guidance and reported a 15-cent per share loss in the June quarter on $80.1 million in sales, which was a sequential decline from the $86.4 million reported in the March period.
Yesterday, after the close, they reported $84.7 million in sales, barely ahead of last year’s $83.4 million, and a six-cent per share loss. So, why did the stock leap $4.37 today? First, because the Street was looking for $80.1 million and an eight-cent loss. Second, it now looks like the company can regain profitablity in the December quarter, at least hitting the Street consensus for $102.7 million and a nine-cent profit. The stock was down 53% for the year to date at yesterday’s close, and this evidence that the turn really is here popped it today.
I agree that the turn is here, but I also think the shorts were badly squeezed today, pushing the stock higher than what it will be trading for next week. Short interest in AFFX was flattish at nine million shares in the first half of the year, and then climbed to 11.7 million in July, 12.4 million in August, 12.7 million in September and 13.7 million in October, or 20% of all the stock outstanding. The short interest ratio — the number of shares sold short compared to average daily volume — soared to 13.71 in October. That’s about double the average stock, and means the short sellers would have to buy every share that traded for 13.71 days of average volume to cover all of their positions.
Affymetrix expanded wafer capacity at its Sacramento factory by 30% in the December 2005 quarter, and another 30% in the March 2006 quarter. It looks like they are now getting the yields up on this new equipment. They also have a new production facility in Singapore that went online in September. As they improve yields, their profit margins will improve. Gross profit margins fell from 70.6% in last year’s September quarter to 56.2%, mostly due to “forward pricing” for the 500K two-chip genome product. “Forward pricing” means that they set the price to produce normal profits at normal yields, which should happen next year.
Affymetrix is a classic razor-and-blades business. They sell instruments like GeneChip loaders, handlers and scanners, and software for workstation analysis to get a customer set up, and they have 1,480 systems in the field. But then the real money comes from selling GeneChips to that same customer for years. That’s why this new approach to cancer chemotherapy is so important — it moves GeneChips from the research lab to the clinical lab, and locks in a high volume of the most complex and most profitable chip sales. Eventually, GeneChip systems will be in every hospital and clinic — even some individual doctor’s offices.
Last November, Affymetrix was expected to do $460 million in sales in 2006 and $550 million in 2007. By March, those forecasts had been reduced to $420 million and $480 million. That’s when I started focusing on AFFX for a potential recommendation, but I just couldn’t see them hitting $420 million in 2006. Coming into this quarter, expectations had been cranked down again to $350 million in 2006 and $385 million in 2007. I think they’ll do a bit over $355 million this year, but they have a good shot at $400 million next year, if they can smoothly accelerate production at the Singapore plant. Street estimates for next year are all over the map, from seven cents a share to 65 cents, with an average of 35 cents. I am looking at 50 cents a share, followed by $1 a share in 2008.
Today’s price action probably establishes $22 as the worst-case low going forward, even in a bad market correction. The breakout point for this move, which I do think will be tested, is $23. So, I want you to buy AFFX on dips under $24, and I think we could see that as early as next week after the short covering subsides. My target is $40 by the end of 2007.
Avian Flu MegaShift
A new study from John Hopkins and the Ben Gurion University in Israel warned that a third of the countries who have pandemic flu plans have not decided how they would distribute medical treatment. The researchers examined 19 plans from developed nations and 26 from developing countries, covering in total 3.8 billion people or about two-thirds of the world’s population. About half of the plans favored antiviral medications like Gilead Science’s (GILD) Tamiflu, while 62% prioritized giving citizens a flu vaccine. That was strange, because no one thinks that it is possible to vaccinate more than one-in-seven (14%) of the world’s population within a year of a pandemic beginning. Antivirals will be the only medical treatment available in most countries.
Most countries prioritized health care workers for the vaccine and antiviral treatments, but policies varied on other groups such as the elderly, essential service workers and children. Almost half of the countries studied had prioritized children, despite a World Health Organization recommendation against it.
I continue to think the world is very unprepared for a pandemic mutation, and that the first bird flu infections in the U.S. will be found during the current migration season — first in wild birds and then in domestic birds. Continue to buy BioCryst (BCRX) all the way up to $19 for my $30 target; Crucell (CRXL) up to $28 for a $50 target, and hold both the Gilead January 2007 $60 LEAPs (GDQAL) for my $20 target, and the 2008 $50 LEAPs (YGDAJ) for my $30 target.
Biotech MegaShift
Millennium Pharmaceuticals (MLNM) announced results this morning. After numerous adjustments, including a restructuring charge to cut employment by 14%, they lost a penny a share on $104.1 million in sales. The Street was looking for a one-cent loss on $111 million in sales, but the good news about the restructuring program outweighed the revenue miss, and the stock rallied 73 cents today. Millennium raised their 2006 guidance, due to milestone payments on sales of Velcade, and now look for a profit from operations of $30 million to $35 million, with a smaller net loss in the $50 million to $60 million area. They had previously projected a $95 million to $115 million loss, so this is a dramatic change with only three months to go in the year.
Millennium also announced a deal with Ortho Biotech, the Johnson & Johnson subsidiary, to help promote Velcade in the U.S. Ortho already markets Velcade outside of the U.S. This gives the drug more firepower against Celgene’s Revlimid, approved in June for the same indication as Velcade — multiple myeloma. The restructuring program also makes them a more attractive acquisition candidate for Genzyme or Ortho. Continue to buy MLNM under $11 — it went over that today — for my $23 target. There is a huge amount of value in this company, and they are finally starting to unlock it.
QLT (QLTI) also announced before the opening this morning. They did $38.2 million in sales and made six cents a share proforma. Like Millennium, it was a confusing report due to write-downs and special items like patent legal fees, but I think it is fair to say that sales were weaker than the $42.4 million expected, while earnings were about on target.
Management cut their estimate for Visudyne sales for the year from a range of $370 million to $385 million down to a range of $340 million to $355 million. My thesis that doctors will move to a combination therapy with Lucentis and Macugen for macular degeneration is not playing out — yet. I still think that will happen, although it may take some results from the current combination clinical trials to make it occur.
The good news is that management raised their estimate for Eligard sales from a range of $100 million to $115 million up to a range of $110 million to $120 million. Proforma earnings for 2006 should hit 25 cents to 33 cents a share. QLTI is reducing headcount by 80 people and slightly reducing R&D.
I’m leaving the buy limit on QLTI at $8, but bringing the target price down to $16 to reflect the more rapid drop in Visudyne sales than I expected. I still think the stock can eventually get into the $20s, when the combination therapy takes off.
Content on Demand MegaShift
Comcast (CMCSA) reported before the opening today, and it was good news. Excluding a 32-cent per share gain from the purchase of Adelphia Communications, Comcast reported 26 cents a share, clobbering the Street forecast for 19 cents. Sales were in line with the Street forecast at $6.4 billion. Revenues were more profitable than expected because they came from a higher number of customers for their $99 phone, digital TV and Internet access service, a high-margin offering. The company signed up 483,000 new digital voice (VoIP) customers, up from 72,000 in the September 2005 period. They added 558,000 digital cable customers, up 77% from last year. About 536,000 bought broadband Internet access, the most for a quarter in two years.
Management said that the December quarter will be “as good or better.” They used phrases like “the third quarter was the inflection point” and “this is just the beginning.” The Street was looking for $6.7 billion and 21 cents in the December quarter, and I think they will now have to raise their earnings estimates dramatically. The stock jumped $1.24 today, and CMCSA remains a strong hold for my $62 target.
Harmonic (HLIT) also reported an excellent quarter, booking $62.9 million in sales, up 18% sequentially and right on the consensus. They could have shipped more, but they had some supply shortages that will be resolved this quarter. U.S. cable and international telco and satellite customers were areas of strength. Earnings hit 10 cents a share, far above the four cents Wall Street expected. Orders were strong, especially for their new video products, and they guided for December-quarter sales in a $67 million to $72 million range, with the midpoint a bit above the $68.2 million consensus. However, Harmonic expects a small sequential decline in gross profit margins, which may be due to the supply constraints or to the expected product mix.
In any case, the Street liked it and Harmonic took a nice $1.47 jump today. Buy HLIT on any dip under $7 for my $12 target. I am thinking about raising both the buy limit and target price, especially if the stock gets caught in a correction in the broad market.
Silicon Image (SIMG) reported after the close. They did a record $78.3 million in sales and earned 24 cents a share proforma, compared to Street expectations for $77.6 million and 21 cents. In the press release, they said they are encouraged by the design wins they have for 2007, and that over 450 companies have now adopted the HDMI standard. The conference call will be starting as this goes on the web, and if they say anything dramatic I will follow up with a Flash Alert tomorrow.
The consensus for the December quarter was $79.0 million and a sequentially flat 21 cents. The company guided for a decline of 3% to 5% due to normal seasonality, or $74.4 million to $76 million. That hit the stock almost $2 in aftermarket trading.
I am not worried about the December quarter, but I am worried that weakness in the U.S. economy in the first half of 2007 could translate to slower sales of high-end consumer electronics products. SIMG is well above my $10 buy limit, and instead of raising my buy limit, I am moving it to a hold for my $18 target.
Telkonet (TKO) installed their new Smart Energy system at The Octagon, a 500-unit luxury apartment complex in New York City. It monitors the amount of energy generated by 240 solar panels on the roof of the eco-friendly building and uses the building’s wiring to transmit the data to controllers and monitors, both on-site and remote. This is the largest solar array in Manhattan. The building owners saved tens of thousands of dollars by not having to run dedicated wiring to the panels and weather data collectors on the roof. The Octagon was built in 1841, and this restoration and conversion to apartments would have been far more expensive without Telkonet’s iWire system. Buy TKO up to $5 for my $15 target.
New Energy Technology MegaShift
Plug Power (PLUG) reported $1.8 million in sales and a 14-cent loss for the September quarter, worse than the $3.5 million and 10-cent loss expected. The company is deferring product revenues at the time of sale, and amortizing them over the life of the contract. But deferred revenue only grew $100,000 in the quarter, so it was weak any way I look at it.
PLUG has received orders for more than 400 systems so far this year, on track for their goal of 500 to 750 orders. They still have plenty of cash left — $278.5 million. With their partners and products, I think they are bound to succeed. But it is taking longer than I expected to get sales traction, so I am reducing my buy limit on PLUG to $5 and my target price to $10 for sometime in 2007. The stock seems to have very strong support around $4, so the risks are more time-related than price-related.
Royal Dutch Shell (RDS.A) announced their September-quarter results before the open today. They clobbered estimates, hitting $84.3 billion in sales and 93 cents a share. Production increased above year-ago levels for the first time since the March 2003 quarter, in spite of their problems in Nigeria. In contrast to BP, they also increased their refining profits.
Earlier this week, they offered $6.8 billion to buy out the 22% interest owned by their partner in the Canadian tar sands operation. The stock jumped $1.82 a share today, and RDS.A remains a buy on any dips under $66 for my $75 target.
Security MegaShift
Packeteer (PKTR) reported $36.0 million in sales and 10 cents a share, compared to the consensus estimate for $37.3 million in sales and 10 cents. The Tacit acquisition, which they closed in the June quarter, was supposed to grow from a $900,000 contribution in the June period to $3 million to $4 million in September, but it fell a little short due to integration issues. The slight miss on revenues is no big deal, and Tacit is expected to double to close to $5 million this quarter. You may see a 14-cent earnings number for the quarter, but that includes a tax credit that I don’t count.
Wall Street continues to love competitor Riverbed (RVBD), giving it a $1.5 billion market cap, in spite of the fact that the company is losing money. Packeteer is bigger than Riverbend and has a much more complete solution for Wide Area Network (WAN) optimization and server/storage consolidation, which are the main markets both companies compete in. Yet, Packeteer’s market cap is only $413 million. Both Gartner and IDC rate PKTR as the market leader in the rapidly expanding WAN optimization market.
Packeteer should grow revenues 25% in 2007 and see improving profit margins. I am raising my buy limit to $11 and raising my target price from $17 to $22.
@Road (ARDI) reported after the close today, and the conference call will be on as this is posted on the web. I will send a Flash Alert tomorrow if anything unexpected comes up. The company did $25.2 in sales and three cents a share proforma, compared to Street expectations for $24.5 million and one cent a share.
The Street was looking for modest growth in the December quarter to $26.9 million and four cents a share, but management said orders were strong. I expect analysts will start increasing expectations, as the company is executing better than they thought. ARDI remains a buy only on dips under my $5.50 buy limit, and I am not changing the $8 target.
Symantec (SYMC) reported a disappointing quarter, and I think this is a signal to us to get out. In contrast to the recent strong report from Check Point Systems (CHKP), Symantec missed their earnings expectations, reporting 22 cents a share compared to the 26-cent consensus. European sales fell short due to execution issues. Sell SYMC.
Video iPod MegaShift
Portal Player (PLAY) announced after the close today, with the conference call starting shortly after this issue is posted on the web. Wall Street was looking for $37.3 million in sales and 12 cents a share, and PLAY missed on the top line with $34.8 million, but came through on the bottom line with 13 cents.
For the December quarter, the Street consensus was for flattish sales and earnings, with $38.9 million in revenues and, again, 12 cents a share. The company gave disappointing guidance of $31 million to $38 million and five cents to 14 cents on the bottom line.
The key to this stock is what happens at Macworld in January. It looks like Apple will introduce the iPhone, which is a cell phone and music player. PLAY has a chip for that. If Apple settles the Burst.com (BRST) lawsuit before then, they’ll also introduce the high-end video iPod. PLAY has a chip for that, too. PLAY remains a buy up to $12 for my $20 target. If they say anything that would change my mind on the conference call, I will follow up with a Flash Alert tomorrow.


