New World Investor – 7.23.26

Michael Murphy
2026-07-24
23
Jul 26

Dear New World Investor:

As I expected, the June Consumer Price Index fell 0.4% from May, thanks to falling gasoline prices (in turn, thanks to falling oil prices). That was the largest single-month decline since April 2020. The CPI was up 3.5% year-over-year, the lowest yearly reading since March. Inflation is dea…not so fast. The core rate increased 0.0% month-over-month but 2.8% year-ever-year, well above the Fed’s 2.0% target.

Click for larger graphic h/t Yahoo Finance

Rent of Shelter was up only 0.13% month-over-month, although still up 3.24% year-over-year. It may have begun its deceleration to 2%. The so-called Super Core (non-housing services) fell -0.09% month-over-month (year-over-year +2.67%). Seasonality is likely to push this idiosyncratic series lower through the summer. The tariff impact is over and core goods are headed back to zero. It is possible that a return to disinflation is coming.

I expect the June 30 core Personal Consumption Expenditures (PCE) Index – the Fed’s favorite inflation indicator – to be a mild +0.2% month-over-month and +3.3% year-over-year. That would be the lowest monthly print since November. The headline PCE should decline 0.07% for June, lowering the year-over-year rate to +3.7%. Still a long way from the +2.0% target, but making enough progress to keep the Fed from raising the funds rate.

The bond market disagrees. The US 30-year bond yield has traded above 5% for 27 days, or about 19% of all sessions. That is the longest stretch since the 50-day stretch in 2007, the beginning of the Great Financial Crisis. Unlike 2007, the Federal Reserve’s benchmark is currently 150 basis points lower than the 30-year. The bond vigilantes are demanding even more compensation for holding the longest maturity sold by Treasury than at the start of the subprime debt woes! They are worried about the growing debt pile and sticky inflation. They are right about the debt but wrong about inflation. I expect the 30-year to go back under 5%.

Since 2007, the Treasury market has ballooned from $4.5 trillion to $31 trillion. Debt as a percentage of US gross domestic product has doubled to over 100%. Years of excessive spending have propelled annual interest cost above $1 trillion.

Debt concerns prompted Lacy Hunt of Hoisington Investment Management, a renowned and probably the last bull on the US long bond for decades, to throw in the towel earlier this month, citing a “broader structural backdrop” of larger fiscal deficits and higher capital demand that could keep inflation and long-end yields higher.

With no bond bulls left, the sellers are out of ammo. In every one of the instances that we saw 5% 30-year Treasurys in the last few years, it was quickly bought by pensions and insurers. One of the tells that we can expect that to happen again is that the two to 10-year Treasury notes have increased much less, only back toward levels last seen in early 2025.

So who is buying stocks in this environment? Well, there is record high foreign demand for US equities, probably to participate in the AI boom their countries are missing:


Click for larger graphic h/t @rev_cap via Jared Dillian

And options traders are their most bullish on stocks since December 2020, after the total put/call ratio plunged to 0.61:

Click for larger graphic h/t @Barchart via Jared Dillian

But people are not running wild on margin debt:


Click for larger graphic h/t @AndreasSteno

Plus, tech insiders are buying into the summer weakness in their stock prices at a robust pace: 28 executives at companies within the State Street Technology Select Sector SPDR ETF (XLK) have purchased their own stock on the open market over the past six months. That’s the highest count on record, according to an analysis by SentimenTrader, and a double since the start of 2026.


Click for larger graphic h/t @SentimenTrader

Money is coming off the sidelines at a rapid clip, which usually means a correction happens soon. It’s a good time to let cash build up, take some profits like my recent recommendation to sell Apple, and get your buy list ready for some low-ball bids.

Market Outlook

The S&P 500 lost 1.8% over the last two weeks, even though the year-over-year index earnings growth rate is tracking at 24.7%. This will mark the second straight quarter of earnings growth above 20%, and the seventh straight quarter of double-digit earnings growth. The Index is up 8.2% year-to-date. The Nasdaq Composite lost 4.1% as Wall Street bailed on AI stocks. It is also up 8.2% for the year. The SPDR S&P Biotech Exchange-Traded Fund (XBI) fell 7.1% as hedge funds took profits. It is still leading the performance derby, up 24.9% year-to-date. The small-cap Russell 2000, like the 500, dropped 1.8%. It is up 18.5% in 2026.

Top 5

Changes this week: None

Near-Term – chronological order
INO Inovio – bounce back from equity offering + FDA allows 6-month review of INO-3107
AKBA Akebia Therapeutics – Vafseo launch
BTC-USD Bitcoin – rebound from sell-off
ETH-USD Ethereum – rebound from sell-off
EQT EQT – natural gas price rebound
USL United States 12 Month Oil Fund, LP – crude should rise quickly

Long-Term – alphabetical order
ABCL AbCelllera – Will become a huge pharma royalty company
UUUU Energy Focus – Domestic uranium supplier
EQT EQT – largest US natural gas company
IBIT iShares Bitcoin Trust – Bitcoin is headed for $150,000
META Meta – a (the?) leader in the metaverse
PLTR Palantir – a (the?) leader in AI applications software
SCYX ScyNexis –First new antifungal in 20 years

Economy

The Atlanta Fed’s GDPNow model estimate for June quarter real GDP ticked up a bit to +1.7%, but it’s still under the Blue Chip economist average of +2.1%. We’ll see the number on July 30.

Click for larger graphic

Coming Events
All times below are ET, and most presentations and slides are archived on the companies’ websites so you can listen to them.

Friday, July 24
Short Interest – After the close

Monday, July 27
GILD – Gilead Sciences – Through 7/21 – 26th International AIDS Conference

Tuesday, July 28
PYPL- PayPal – 8:00am – Earnings conference call

Wednesday, July 29
Business Employment Dynamics – 10:00am – December quarter revisions
VET – Vermilion Energy – After the close – Earnings release; call tomorrow
Fed Meeting – 2:00pm press release; 2:30pm press conference
META – Meta Platforms – 4:30pm – Earnings conference call

Thursday, July 30
June quarter GDP – 8:30am – First estimate
Personal consumption Expenditures (PCE) Index – 8:30am
VET – Vermilion Energy – 10:00am – Earnings conference call
AG – First Majestic – 11:30am – Earnings conference call
SNAP – Snap – 5:00pm – Annual meeting

Monday, August 3
ON – Onsemi – 5:00pm – Earnings conference call
PLTR – Palantir – 5:00pm – Earnings conference call
SNAP – Snap – 5:00pm – Earnings conference call

Tuesday, August 4
Job Openings and Labor Turnover Survey (JOLTS) – 10:00am
GILD – Gilead Sciences – 4:30pm – Earnings conference call

Wednesday, August 5
CDE – Coeur Mining – After the close – Earnings release; call tomorrow
RGLD – Royal Gold – After the close – Earnings release; call tomorrow
FSLY – Fastly – 4:30pm – Earnings conference call
ABCL – AbCellera – 5:00pm – Earnings conference call

Thursday, August 6
CDE – Coeur Mining – 11:00am – Earnings conference call
RGLD – Royal Gold – 12:00pm – Earnings conference call

Friday, August 7
July payrolls – 8:30am

Big Tech: The Biotech & Digital Dominators MegaShift
There are at least four ways to make money in the stocks of these large, growing, dominant companies. You can:
* * Buy a stock and hold it
* * Buy a stock and write a call option against it
* * With a Level IV options account, write an out-of-the-money put option
* * With a Level IV options account, write an out-of-the-money put option and use part of the premium to buy an out-of-the-money call option

Gilead Sciences (GILD – $130.86) is expected to report June quarter revenues up 4.57% to $7.41 billion with a loss of $7.29 per share due to one-time acquisition writeoffs. They should report about $1.90 before the writeoffs.

They will present the detailed outcomes from the Phase 3 ISLEND-1 and ISLEND-2 trials at the 26th International AIDS Conference on July 29. The primary endpoint results at Week 48 showed that the investigational once-weekly oral single-tablet HIV treatment regimen of islatravir 2 mg/lenacapavir 300 mg (ISL/LEN) was effective in adults living with HIV who were virologically suppressed and switched from Gilead’s global guideline-recommended Biktarvy (ISLEND-1) or other standard of care oral daily antiretroviral regimens (ISLEND-2).

I expect the ISL/LEN combination of Merck’s islatravir and Gilead’s lenacapavir to be approved by the FDA as the first and only once-weekly oral HIV treatment option for adults with virologic suppression on a stable antiretroviral regimen.

Leerink Partners downgraded Gilead from outperform to market perform and cut its target price from $146 to $127. It sees headwinds in the growth of the HIV prophylaxis (PrEP) market and reduced their 2031 estimates for annual US sales of Gilead’s PrEP portfolio from $6 billion to $4 billion. That’s about in the middle of the consensus for $3.1 billion to $5.3 billion, so they were just too enthusiastic and this cut is no big deal. GILD is a Long-Term Buy under $115 for a first target of $150.

Meta Platforms (META – $606.10) is expected to report June quarter revenues up 26.82% to $60.26 billion with earnings of $7.39 per share. But the two things that will move the stock are (1) any update to their capital spending guidance (already doubled once for 2026 to $125-$145 billion), and (2) Meta’s ability to monetize their AI infrastructure investments. Meta’s recent pivot toward becoming a neocloud provider and compute lessor (Meta Compute), including a potential $10 billion, two year Anthropic deal, could reduce its persistent valuation discount by providing a path to such monetization.

Of course, analysts will also be looking at the integration of AI models within Meta’s social ecosystem and the scaling of Meta Glasses, both key forward catalysts. I think their AI-driven ad improvements could add $7–$12 billion in annual revenue, and Meta Glasses has a huge cost advantage over Apple and Snap’s AR glasses. A team of Jefferies analysts put Meta’s AI glasses through their paces and came away impressed with their functionality, performance, and design that represents a “long-dated growth vector for Meta not yet priced in,” and separates Meta AI glasses from its competitors.

The team was impressed overall with the quality of the glasses, their functionality, and monetization potential for Meta, with additional long-term upside from premium subscriptions, advertising, and commerce, along with the multi-billion dollar hardware revenue opportunity. They wrote: “We believe Meta has the first-mover advantage as the only player shipping AI glasses at scale today versus peer products still underway.”

Meta’s manufacturing partner, EssilorLuxottica plans to double production capacity to 20 million glasses this year.

BofA reiterated their Buy rating and $835 price target, saying an internal Meta memo reviewed by Reuters suggests the company could expand computing capacity more efficiently than previously estimated. Meta expects to deploy about 6.5 gigawatts of AI compute capacity during 2026, including 5.5 gigawatts in the second half of the year. Meta’s projected capital spending of roughly $145 billion implies construction costs near $22 billion per gigawatt, compared with BofA’s earlier estimate of about $45 billion per gigawatt.

The stock was added as a new long idea at Hedgeye, with the potential upside to $1,200+ over the next 12-18 months. They wrote: “We have been saying that 2H26 into 2027 is the highest-probability period of outperformance for Meta, based on our expectation for when the company would release a frontier model, when its AI capacity would begin coming online, and the base effects related to expense growth. And here we are: Muse Spark 1.1 shipped on July 9, the capacity Meta began building in late 2022 starts coming online in the back half of this year, and the labor-to-capital shift is comping against last year’s expense base – while the stock still trades at a discount, with zero revenue modeled for Meta Compute.” META is a Buy under $705 for a long-term hold.

Nvidia (NVDA – $208.76) won’t report their July quarter earnings until August 26, but you can be sure they’ll be another blowout.

I have a couple of problems with Nvidia and the whole AI trade in general. Preamble: I think AI is the Fourth Industrial Revolution that will dramatically increase the standard of living. That’s why I’m going to restart the California Technology Stock Letter.

But…

First, I suspect about half of all the Nvidia GPUs that have been shipped are in warehouses, unused. It turns out that building a data center – land, concrete, plumbing, wiring, getting enough water, getting enough power – is really hard. Even if that should happen. Perhaps, as Mark Cuban said, most of them will wind up being used as pickleball courts.

Second, the interlocking investments and revenues, plus all the off-balance sheet debt, is beginning to look like the 2008 subprime real estate crisis. The subprime entity at the center of all this is OpenAI. I’ve said before that I expect them to go bankrupt in 2027, and that shock will be transmitted through all the interlocking circular financings through the whole sector. There are some great companies that will come out of this, including Nvidia, Palantir, and Meta. But as we know, when the paddy wagon comes they take everyone, and sort it out later. The dotcom crash bankrupted Pets.com and gave you a chance to buy Amazon at $9 a share.

I’m thinking out loud here, and I’m not quite ready to say this is the hill I will die on, but I’m getting close. AI can do most of the left-brain work in the world much faster and better than humans. It can do none of the right brain work, which is a major reason Artificial General Intelligence (AGI) is horse manure whose real use is raising money.

For now, Nvidia is the top beneficiary of the AI infrastructure buildout. Its CUDA software and proprietary foundational AI models, such as Nemotron and Cosmos, strengthen its GPU business and ecosystem lock-in. They are early to some of the next huge markets: quantum computing, physical AI, and digital biology, leveraging their software platforms and direct investments. I don’t think the cheaper Chinese AI models or the hyperscalers’ custom silicon will slow them down.

And, as CEO Jensen Huang says, the much-feared AI apocalypse is complete nonsense:

NVDA’s Vera CPU + Rubin GPU architecture enables 35x lower compute costs, accelerating agentic AI adoption and expanding their total addressable market. Jensen recently directly refuted the recent rumors of Vera Rubin and Kyber production delays. The Kyber rack innovations are set to double GPU density and drive the next phase of their AI revenue expansion. An on-track Kyber roadmap would mean the company will beat Wall Street’s second-half data center revenue expectations by 20% or more.

Yet the stock is trading at a forward P/E multiple near its five-year lows, despite expectations for 88% forward EPS and 82% revenue growth. At around 16x 2028 earnings, NVDA is a Buy for a $225 first target.

Onsemi (ON – $90.13) is expected to report June quarter revenues up 8.19% to $1.59 billion with earnings of 72¢ per share. We bought ON right – it is one of a select group of 25 US large-cap stocks, all with market capitalizations exceeding $10 billion, that have emerged as clear favorites, earning unanimous Buy or Strong Buy ratings from Wall Street analysts. It is up +73.2% year to date.

The $7 billion Synaptics acquisition will increase product competitiveness and expand its portfolio. ON’s total product count will rise by 23.5%, with CPUs and DSPs from Synaptics driving an 8.45% increase in addressable market size by 2030. After the acquisition, I expect ON’s 4-year forward average growth rate to improve by 5.23% to 16.68%, mainly through enhanced product offerings rather than revenue synergies. ON is a Buy under $60 for a $130 first target.

Palantir (PLTR – $123.37) is expected to report June quarter revenues up 80.41% to $1.81 billion with earnings of 35¢ per share. In the March quarter, Palantir generated 85% revenue growth while operating expenses rose only 32%, driving 60% adjusted operating margins and 57% free cash flow margins. Stable stock-based compensation alongside rapidly growing revenue is allowing earnings and free cash flow to compound much faster than sales.

Two of the key metrics I’ll be looking for are Remaining Performance Obligations – future revenues – and Net Dollar Retention, which compares how much a customer spends this year to what they spent last year. In the March quarter, Remaining Performance Obligations surged 134% to $4.5 billion. while the 150% Net Dollar Retention showed expanding customer spending after deployment.

Citi raised their earnings estimates today, citing a potential boost in Palantir’s commercial segment’s growth, and reiterated their Buy recommendation, but lowered their target price from $225 to $200. They said: “We expect US Commercial to rebound after an unexpected deceleration in Q1, driven by improved resource prioritization and AIP proliferation across new industries and geographies. PLTR’s post-Q underperformance (-8% vs. IGV +6%) makes the risk/reward more attractive. Intra-Q checks were positive across both commercial and federal, alongside encouraging feedback from CFO Glazer, which gives us more confidence in USC RDV QoQ net adds rebounding to the $800M+ seen in 2H25, driving further upward revisions into FY27.”

Citi now expects 53% revenue growth in fiscal 2027, compared to Wall Street’s estimates of around 45%, with Commercial seeing 67% year-over-year growth. They said intra-quarter checks with partners and management were “largely positive,” citing continued momentum from global systems integrators and independent software vendors partners. They added: “Expanding customer use cases and geographies continue to underscore PLTR’s products and GTM differentiation, which is resonating with enterprise C-suites. In our meeting with CFO Glazer, we discussed notable customer wins from AIPCon 10, particularly in the Legal and Neoclouds verticals. International commercial momentum remains strong, highlighted by a large insurance win in Mexico and deepening relationship with NVDA in Sovereign. On federal, we observed expanding use cases within the DoW at the AWS Summit, and the USDA contract could provide continued tailwinds into 2H. While competitive displacements have increased, we believe the growing set of reference customers will serve as a catalyst for sustained momentum.”

PLTR is a Buy under $160 for a $200 first target.

PayPal Holdings (PYPL – $56.00) is expected to report June quarter revenues up 2.26% to $8.48 billion with earnings of $1.28 per share. The Board said the $60.50 per share ($53 billion) takeover bid by rival Stripe and private equity firm Advent International undervalues the company, and they are right. I expect the company’s $6 billion in free cash flow and $9.34 billion cash balance will attract either a competing bidder or, more likely, a dramatic increase in Stripe’s offer closer to $80–$100 a share.

PayPal’s 440 million active accounts, dominant Venmo presence, and strategic positioning in stablecoins and AI-driven payments make it a potential winner in the digital finance transformation. The branded checkout still faces structural pressure from frictionless card-linked wallets, which drives up customer acquisition costs and compresses margins – just as it did when I recommended this turnaround. Those are solvable problems, as Stripe and Advent know. There is a risk the stock falls back if Stripe pulls their offer, but that would just be another chance to buy under my limit. For now, Hold for a higher offer or PYPL is a Buy under $50 for a triple in three years.

Snap (SNAP – $4.41) is expected to report June quarter revenues up 13.85% to $1.53 billion with earnings of 6¢ per share. In the March quarter, revenue grew 12% year-over-year, driven by increases in Average Revenue Per User (ARPU). Their aggressive cost-cutting, targeting $500 million in annualized savings, positions the company for profit margin expansion and GAAP breakeven. It is selling for only 1.2x sales and 8x pro forma earnings – very cheap if margin expansion materializes, even with modest growth. SNAP is a Buy under $11 for a $17+ target.

SoftBank (SFTBY – $17.64) CEO Masayoshi Son said that AI will need about $5 trillion in annual investment by 2040, called AI bubble concerns “absurd” and predicted the technology will transform the global economy. Speaking at SoftBank World 2026 in Tokyo, he said, “Every year $5 trillion, or 800 trillion yen, you might think that’s a lie, but I am confident that’s what it will cost.”

He dismissed AI critics, comparing them to people who once rejected automobiles and airplanes. “Those who dislike AI have essentially refused their own evolution,” he said, adding that those who condemn AI are “spitting upwards.”

He predicted AI would account for 20% of global GDP by 2040, generating about $46 trillion in annual revenue and around $23 trillion in profits, which he said would justify the massive investment required to build AI infrastructure. Looking further ahead, Masa said AI data centers will require about 3 terawatts of power generation by 2040—roughly 1.8 times current global electricity consumption. He said natural gas would initially be the primary energy source before nuclear fusion eventually takes over.

Masa is all-in on AI, including AGI, which I think is not going to happen this century. He said: “We will go from a human-centric world to an agent-centric world. The age when humans are the highest life form on earth will end. For better or for worse, it will happen and it can’t be stopped.”

That is BS. SoftBank’s cumulative investment in ChatGPT maker OpenAI is expected to exceed $60 billion before the end of 2026. Keep your sneakers laced for now, but expect to exit soon. Hold SFTBY for a first target of $50 and then higher as the discount to hard book value disappears.

Small Tech

Enovix (ENVX – $4.34) has a unique, patented 3D stacked silicon-anode battery architecture that delivers higher energy density and dramatically reduces fire risk versus conventional lithium-ion batteries. The company has a fortress balance sheet, ramping production, and imminent commercial milestones in smart eyewear and smartphone batteries. After smartphone commercialization, there is licensing potential for their architecture that would drive high-margin, recurring revenues and significantly expand earnings beyond current manufacturing capacity.

To get everything over the finish line, they hired former Apple executive Michael Vyvoda as Chief Operating Officer, effective July 29. ENVX is a Buy up to $20 for a 4-year hold to $100+ as their BrakeFlow lithium-ion battery takes market share.
Primary Risk: A new competitor invents a better battery.

Fastly (FSLY – $19.43) is expected to report June quarter revenues up 16.95% to $173.92 million with earnings of 7¢ per share. Their revenues are driven by diversified demand across AI, cybersecurity, and IoT, not just AI hype. Their programmable edge computing and consumption-based model appeal to AI developers.

The company’s17.90% levered free cash flow margin and attractive price/sales ratio offset concerns about negative net income due to stock-based compensation. FSLY is a Buy under $10 for a 3- to 5-year hold to $50+.
Primary Risk:Content and applications delivery networks are a competitive area.

QuickLogic (QUIK – $13.35) has suffered a 50% selloff, yet they have several revenue growth drivers: Intel 18A contracts, RadPro defense programs, and a growing storefront product model that promises higher, more predictable margins. They need to convert delayed contracts to revenue, continue the stellar gross profit margin recovery, and close more commercial Intel 18A contracts – and CEO Brian Faith knows it. QUIK is a Buy up to $10 for my $40 target as their earnings repeatedly surprise Wall Street.
Primary Risk: Customers’ product introductions and associated royalties are unpredictable.

ARK Venture Fund (ARKVX – $54.99) is up since the SpaceX IPO, even though SPCX is below the IPO price. That’s because the current price of SpaceX is far above the last venture round.

The good news here is that 4.59% of the fund is in Anthropic, which should be the next big IPO, probably in October. Anthropic raised $30 billion in a Series G in February 2026 at a $380 billion valuation. Forge Global places the current secondary valuation at $1 trillion. Hiive, a separate regulated US secondary market for accredited investors, comes in at $851 billion, within 18% of that number. Jupiter’s Prestocks market confirms $1 trillion. Three independent pricing mechanisms pointing at the same number is not noise. That is the market arriving at a consensus.

Amazon committed $25 billion to Anthropic on April 20, and Google committed $40 billion on April 24. Anthropic’s revenue went from a $9 billion annual run rate at the end of 2025 to $30 billion by early April 2026 – one of the fastest revenue ramps in enterprise software history.

The bad news here is that an even larger 6.33% of the fund is in OpenAI, so we will have to exit ARK Venture Fund after the Anthropic IPO. ARKVX is a Buy for the Anthropic IPO.
Primary Risk: Cathie sells the stock before the IPOs.

Biotech MegaShift
Biotechnology market expansions historically trail technology sector surges by about 24 months. As successive advancements in computing infrastructure permeate the market and generate substantial capital, these resources and technological capabilities systematically transition into the life sciences sector. Operational tools originally developed to revolutionize information systems are invariably adapted for biological applications.

This cyclical pattern is evidenced by historical precedents: the proliferation of personal computing preceded the emergence of Genentech and Amgen, while the Internet expansion laid the groundwork for Regeneron and Illumina. Currently, the artificial intelligence paradigm shift transforming the broader economy is in the initial phases of integration within the biological sciences. Over the next decade, AI is projected to significantly accelerate drug discovery timelines, optimize the utility of legacy compounds, and generate substantial enterprise value across the pharmaceutical industry.

If you can afford it – and it would not be too big a position in your portfolio – putting $2,000 into each of these speculative biotechs might be a good way to start. Buying these out-of-favor, fallen, or forgotten companies that can get important products through the FDA at very low market capitalizations seems like a good strategy to me.

Risks

Development-stage biotechs are subject to investor sentiment swings from wildly optimistic to excessively pessimistic – mostly the latter recently. After the Primary Risk for each company, I’ve added the clinical stage of their lead product, the probable time of their first FDA approval, and the probable time of their next financing.

As always, you need to think about an appropriate position size. You could buy a full position upfront and then just hold on, or buy some upfront and leave room to add more on the inevitable financings, transient clinical trial setbacks, and the like

AbCellera Biologics (ABCL- $5.67) is expected to report June quarter revenues down 54.44% to $7.78 million with a loss of 12¢ per share. As always, it will be news about clinical progress or partnerships that move the stock.Buy ABCL up to $6 for a long-term hold to $30 or more.
Primary Risk: Partnered and owned drugs fail in the clinic.
   Clinical stage of lead product: Partnered: Various Owned: Preclinical
   Probable time of next FDA approval: 2027-2028
   Probable time of next financing: 2026-2027 or never

Akebia Therapeutics (AKBA- $1.22) next quarterly report will show Vafseo adoption accelerating. The new dosing regimen of three-times-a-week in the dialysis center is driving strong patient and prescriber growth, with 60% sequential patient expansion and adherence rates at 86%. An announcement that DaVita will offer Vafseo could come anytime, as could an announcement that the FDA has agreed to a much less burdensome trial in non-dialysis patients with chronic kidney disease. Buy AKBA up to $4 for the Vafseo launches in the EU, UK, and US. I think GSK and/or Amgen will make a bid for the company.
Primary Risk: Vafseo doesn’t sell in the US.
   Clinical stage of lead product: Approved
   Probable time of next approval: 2027
   Probable time of next financing: Never

Compass Pathways (CMPS – $11.71) published an important paper in the Journal of Psychopharmacology. A post-hoc analysis of support methods used in an open-label Phase 2 COMP360 study in PTSD showed that monitoring and support provided during treatment administration sessions were (1) minimal, (2) non-directive, and (3) distinct from conventional conceptions of psychotherapy. This will tell the FDA that COMP360 is providing the benefits seen in the clinical trials, not the psychological support.

A memorandum of understanding between HHS and the Veterans Administration is good news for Compass. The MOU is intended to bolster “collaboration on the research, clinical development, and responsible deployment to veterans suffering from serious mental health conditions of potential future rapid-acting psychedelic drug products if approved by the Food & Drug Administration.”

Eli Lilly is acquiring psychedelic drug maker AtaiBeckley for $2.8 billion upfront, with up to $1 billion more tied to milestones. AtaiBeckley’s lead drug, BPL-003, is a nasal spray currently in Phase 3 trials for treatment-resistant depression. It is a synthetic form of the psychedelic compound 5-Meo-DMT, not psilocybin. CMPS is a Buy under $10 for a very long-term hold to $200.
Primary Risk: Their drugs fail in the clinic.
   Clinical stage of lead product: Phase 3
   Probable time of first FDA approval: 2027
   Probable time of next financing: Never

Inflation MegaShift

Gold ($4,052.30) was hit today but seems to have a solid bid – possibly from one or more central banks, at $4,000.

Click for larger graphic

Miners & Related

Coeur Mining (CDE – $15.24) is expected to report June quarter revenues up 158.38%(!) to $1.24 billion with earnings of 27¢ per share. The company said it is investing $158 million in exploration across its Palmarejo and Las Chispas gold-silver operations in Mexico in 2026, double the previous year’s spending and the largest program in the company’s history. The increased 2026 spending, which includes $27 million and 51.5 miles of drilling at Palmarejo and $24 million and 73.9 miles of drilling at Las Chispas, will support additional drilling at Palmarejo’s underground deposits as well as expanded testing of satellite targets and regional prospects across the company’s land package. Palmarejo produced 6.5 million ounces of silver and 101,000 ounces of gold in 2025, accounting for 36% of Coeur’s total silver production and 24% of gold output. Las Chispas produced 5.1 million ounces of silver and 55,000 ounces of gold last year.

The company has transformed itself into a diversified North American precious metals producer after acquiring New Gold, shifting away from its silver-miner legacy. With a net cash position, expanded buyback, and first-ever dividend, CDE is financially robust and trades at a significant valuation discount to peers like Hecla. CDE is a Hold as gold goes higher.
Primary Risk: Prices of precious metals fall due to US dollar strength.

Dakota Gold (DC – $4.68) was interviewed by Rick Rule (interview starts at 1:20):

DC is a Hold for a $6 target as gold goes higher.
Primary Risk: Robert Quartermain doesn’t find enough gold. Secondary risk: Prices of precious metals fall due to US dollar strength.

First Majestic (AG – $16.45) is expected to report June quarter earnings of 29¢ per share versus 4¢ last year. They reported June quarter production of 3.8 million silver ounces (+2.6% year-over-year), 34,660 gold ounces (+2.3%), 16.5 million pounds of zinc (+2.6%), 9.0 million pounds of lead (+0.1%), and 252,938 pounds of copper (+23.2%). Their 2026 guidance is for 14.6–15.5 million silver ounces and 128,000–135,000 gold ounces.

First Majestic offers high leverage to silver with improved fundamentals and a cleaner portfolio after the two non-core asset sales of San Martin for $90 million and Del Toro for up to $60 million. These sales converted idle assets into liquidity to support capital spending for growth projects like Santo Niño. CEO Keith Neumeyer was at the Rule Symposium (interview starts at 2:23):

AG is a Buy under $11 for a $23 next target price as production increases and the price of silver rises.
Primary Risk: Prices of precious metals fall due to US dollar strength.

Royal Gold (RGLD – $199.64) announced preliminary financial results for the June quarter, although they won’t announce earnings until August 5 with the conference call on August 6. Stream segment sales hit $311 million, and Royalty segment sales will be $137-$142 million.

During the quarter, they repaid another $200 million of debt, resulting in an outstanding balance on their revolving credit facility of $400 million at the end of June, leaving $1.0 billion undrawn and available. They bought back 147,205 shares at an average price of $203.80 per share, for total consideration of $30 million. RGLD is a Buy under $180.
Primary Risk: Prices of precious metals fall due to US dollar strength.

Cryptocurrencies

Cryptocurrencies are a diversifying asset that offer a unique opportunity to make (or lose!) a lot of money quickly.

Bitcoin (BTC-USD on Yahoo – $64,765.66) spent years selling a story because building a real, legal, revenue-generating token business in America was nearly impossible. So companies sold promises instead. Now the rules have changed. Wall Street came in, regulations cleared, and for the first time, the top-performing crypto companies all have one thing in common: They can make money.

I see two remaining problems for bitcoin. First, marginal liquidity would rather speculate in prediction markets and equity markets. The gamblers are gone, and I don’t really miss them. Second, the marginal energy to mine bitcoin is worth 10x-20x if reallocated to serving AI tokens. That will go away and, in the meantime, a lower supply of new tokens should mean a higher price for the existing ones.

Click for larger graphic

BTC-USD, ETH-USD, IBIT, and ETHA are Strong Buys.
Primary Risk: Bitcoin falls due to over-regulation or is surpassed by another cryptocurrency.

iShares Bitcoin Trust (IBIT- $36.65) remains the cheapest and easiest way to buy bitcoin. IBIT is a Buy for the 2028, 2032, and 2036 halvings.
Primary Risk:Bitcoin falls due to over-regulation or is surpassed by another cryptocurrency.

iShares Ethereum Trust (ETHA- $14.11) remains the cheapest and easiest way to buy ethereum. ETHA is a Buy for the coming explosion in token-funded start-ups.
Primary Risk: Ethereum falls due to over-regulation or is surpassed by another cryptocurrency.

Commodities

Oil – $91.94

Well, well. It turns out that when the end user demand for oil and gasoline is growing and the supply is impaired, using oil in storage to paper over the gap doesn’t work forever. The Energy Information Agency reported oil in storage fell 1.7 million barrels and oil in the Strategic Petroleum Reserve (I hope there’s not a surprise strategic reason to need it!) fell 3.0 million barrels, for a total draw of 4.7 million barrels.

Total US stockpiles of crude oil have fallen to just 43 days worth of consumption, the lowest level in 45 years. This comes as the war in Iran re-escalates, including a recent announcement from Iran’s proxy militia – the Houthis of Yemen – of a maritime embargo against Saudi Arabia. This embargo threatens to disrupt 4.5 million barrels per day of Saudi oil exports flowing through the narrow Bab al-Mandab Strait. The risks of a significant oil supply crunch are rising.

In rapid order, multiple Russian tankers were taken out in the Black Sea, essentially showing Russian Black Sea oil loadings are finished (1 million barrels a day of exports) because Russia apparently cannot protect Black Sea ships. Then Iraq ended tanker loadings due to a drone attack at their VLCC terminal. The Houthis are making noise that they, in fact, will shut the Red Sea. Then the US put a missile into an Iranian-bound tanker, showing the blockade is once again real. And WTI is not even over $80? I cannot explain this in any way that doesn’t sound like a stupid conspiracy theory.

The latest Chinese customs data revealed that the country’s crude-oil imports dropped by a record 41% in June. The 7 million barrels per day decline in demand from the world’s largest energy importer helped balance supply disruptions from the closure of the Strait of Hormuz. But this is merely a temporary balancing act as China draws down its strategic petroleum reserves, setting up a rebound in global demand when Chinese imports come back into the market.

Crude oil prices have finally ticked up as military activity between the US and Iran reignited, yet they remain far off their wartime highs. But red flags are flashing in the refining market for critical products such as gasoline, diesel, and jet fuel. “Crack spreads,” or the price difference between crude oil and the refined product, keep growing. That means that despite the drop in oil prices, the underlying physical reality is still much tighter.

Click for larger graphic h/t Yahoo Finance

The most closely watched spread is the “3-2-1 crack,” which estimates the theoretical margin gained from turning three barrels of crude oil into two barrels of gasoline and one barrel of distillate fuel (diesel). That crucial measure pushed past $60 to reach an all-time high near $64. Refiners are earning their best margins on record, but US refiners have been running at or above the 95% utilization rate that’s widely regarded as full capacity for almost two months. In the Rocky Mountains region, fuelmakers have surpassed the 100% mark twice in the past few weeks, a pace that even the refining industry’s main lobbying group warns is untenable.

Running near max capacity is raising the likelihood that equipment failures tighten fuel supply and amplify price volatility. Several major refiners already have postponed maintenance to keep capacity online. Motiva Enterprises delayed a turnaround at the biggest crude unit at its Port Arthur refinery in Texas by a year to the fall of 2027. Any major outage could have an outsized impact because domestic fuel stockpiles are unusually low. According to Bloomberg, inventories have been strained by a drop in gasoline imports to a 29-year seasonal low and robust demand for US diesel to replace production lost to the conflicts in Russia and the Persian Gulf. Morgan Stanley says that more than half of Russian oil refinery capacity is down due to Ukrainian attacks. Typically, Russia is the world’s second-largest diesel exporter – normally around 11% of global seaborne trade.

As governments and companies drew down their jet fuel and gasoline stores during the Iran war, refineries struggled to obtain crude oil to replenish their inventories, driving prices higher. The dynamic has played out just as the US hit the summer vacation season, when demand for gasoline spikes.

The September 2027 Crude Oil Futures (CLU7.NYM – $72.82) moved up, but are still a Buy under $75 for my (lowered) $100+ target. Only buy futures for all cash; do not use margin.

The United States 12 Month Oil Fund, LP (USL – $51.94) is a Buy under $40 for a $100+ target.

Vermilion Energy (VET – $11.24) is expected to report June quarter revenues down 12.14% to $469.3 million. The company got TSX approval to repurchase up to 15.16 million shares, around 10% of its public float. Management expects to return 40% of excess free cash flow to shareholders in 2026, primarily through dividends and share repurchases.

TD Cowen upgraded VET from Hold to Buy with a C$18 price target, saying the shares are at a compelling entry point following their recent underperformance. They said Vermilion’s recent operational headwinds (presumably the falling oil price) are increasingly understood by investors, while portfolio repositioning has improved asset quality, unit costs, and financial flexibility. They see a free cash flow inflection potential in 2028 and beyond, momentum in Germany, and a valuation that offers reasonable compensation for the remaining execution and timing risks.

2026 volumes are tracking toward the high end of the company’s guidance for 118,000-122,000 barrels of oil equivalent per day. VET is a buy under $11 for a target price of $24 or more.
Primary Risk: Oil and natural gas prices fall.

Energy Fuels (UUUU – $12.01) produces both uranium and rare earths, a double win. The International Energy Agency (IEA) warned Thursday that China’s full implementation of rare earth export controls could jeopardize $6.5 trillion in global downstream production outside the country. In other news, the IEA said the sun might rise tomorrow.

The Agency said there is a strong case for policymakers to focus more attention on strategic minor minerals – those for which markets are small, but any supply disruptions could carry an outsize economic impact. Energy Focus is there. Critical minerals generally account for a small share of final product prices, suggesting that the additional cost of diversifying the supply chain could be absorbed with limited impact on consumers. For example, critical minerals account for around one-quarter of battery cell costs but only about 3% of the price of an average electric vehicle, while rare earths represent around 40% of permanent magnet costs, but less than 1% of a vehicle’s value. UUUU is a buy under $8 for a $30 target.
Primary Risk: Uranium prices fall.

EQT (EQT – $53.39) reported June quarter revenue down 29.0% from last year to $1.81 billion. The drop was expected – the consensus estimate was $1.84 billion. Total sales volume during ‌the quarter rose 11% from last year to 634 billion cubic feet equivalent (Bcfe), but EQT’s realized price including hedges slipped 5.7% to $2.65 per million cubic feet equivalent (Mcfe) from $2.81 in the year-earlier quarter. Pro forma earnings of 39¢ a share missed by a penny.

On the conference call (WEBCAST HERE and SLIDES HERE and TRANSCRIPT HERE), CEO Toby Rice guided the September quarter to 570-620 (Bcfe) and increased the full year by about 90 Bcfe to 2,375-2,450 Bcfe, citing infrastructure investments that are boosting output. He trimmed their capital spending outlook by $25 million for the full year. He mentioned that before the Iran conflict, they saw 2028–2029 as a little bit oversupplied, but that’s gone away with Iran. He mentioned spot prices internationally are north of $17.

His two key announcements were (1) a definitive 10-year agreement to supply 325 million cubic feet per day of natural gas to Competitive Power Ventures’ Shay Energy Center in West Virginia, a new 2.1-gigawatt power generation facility expected to enter service in early 2031, with pricing linked to PJM power markets rather than a gas price index, and (2) a new LNG offtake agreement, a five-year 500,000 metric tons a year deal with a large Asian integrated energy company, starting in 2028.

Toby also said they have secured all the key regulatory approvals for the Mountain Valley Pipeline Southgate project and will accelerate $85 million in capital contributions to support completion of the pipeline by year-end 2026.

EQT had $330 million of free cash flow in the quarter, despite natural gas prices averaging just $2.89 per million British Thermal Units during the quarter. They are about to hit their long-term net debt target of $5 billion. In the near term, they intend to accumulate cash to aggressively deploy into share buybacks during the industry’s episodic down cycles.

EQT is positioned for significant upside from rising US natural gas demand, driven by LNG exports and data center power needs.

Click for larger graphic

Wall Street is underestimating the potential. If Henry Hub prices rise as projected, EQT could see earnings before interest, taxes, depreciation and amortization (EBITDA) increase by 40% or more from 2028 onward. EQT is a conservative AI-linked trade with minimal downside risk and is a Buy under $70 for a long-term hold for much higher prices.
Primary Risk:Natural gas prices fall.

Freeport McMoRan (FCX – $63.50) reported June quarter revenues down 7.3% from last year to $7.03 billion due to the Grasberg mine closure. They beat the $6.75 billion consensus. Pro forma earnings of 74¢ a share also beat the consensus for 62¢.

Consolidated production totaled 786 million pounds of copper, 192,000 ounces of gold, and 23 million pounds of molybdenum. Consolidated sales totaled 710 million pounds of copper, 123,000 ounces of gold, and 25 million pounds of molybdenum.

On the conference call (WEBCAST HERE and SLIDES HERE and TRANSCRIPT HERE), CEO Kathleen Quirk guided September quarter production to a slightly lower 750 million pounds of copper, 160,000 ounces of gold, and 22 million pounds of molybdenum. For the full year, consolidated sales are expected to approximate 3.1 billion pounds of copper, 650,000 ounces of gold, and 93 million pounds of molybdenum.

Kathleen said: “Our Grasberg ramp-up plans are on track,” adding that the company has formally applied to extend its Grasberg operating permit beyond 2041 and hopes to have a decision by the end of this year.

Click for larger graphic

She said: “We are nearing an investment decision for a major expansion of our Bagdad mine in Arizona and advancing our regulatory work in Chile for a significant expansion at our El Abra mine.

“During the quarter, we increased our ownership in Cerro Verde… bringing total purchases over an approximate 2-year time frame to over $300 million, increasing our ownership by 2% to over 55%. In addition, we returned $600 million to shareholders in the first half, including roughly $200 million in share repurchases.

“Production rates at the Grasberg Block Cave doubled during the quarter from an April average of 34,000 tons per day to an average of 69,000 tons per day in June. Consistent with our April update, we continue to target overall rates in the district approximating 65% of full capacity in the second half of this year, reach 80% by mid-2027, and approach full capacity by the end of 2027.

“Our current estimate for 2026 average unit net cash cost approximates $1.90 per pound, slightly below the April estimate of $1.95 per pound, with higher by-product credits more than offsetting other unit cost increases. As we move through 2026, we expect a large increase in second half sales volumes driven by higher volumes at Grasberg and our U.S. operations.”

EVP & CFO Maree Robertson gave their first 2027 outlook. “For 2027, we expect annual copper sales to increase by more than 20% compared with 2026 and gold volumes to increase by more than 50%, with additional growth projected in 2028 for both copper and gold. 2027 capital expenditures are estimated at $4.8 billion, approximately $300 million above the April estimate, reflecting investments in upgraded mining equipment and revised cost estimates.”

Copper isn’t buying gold’s breakdown. After rallying strongly together through most of 2024 and 2025, gold has fallen roughly 28% from its January 29 record near $5,595 an ounce – its worst quarterly decline in 13 years – while copper is up nearly 10% over the same period and within striking distance of an all-time high. Gold’s recent decline appears to be a reaction to extreme sentiment and crowded positioning, not the end of the commodity bull market.


Click for larger graphic h/t Porter & Co.

FCX is a Hold for higher copper prices .
Primary Risk: Copper prices fall.

* * * * *

Legendary Investor Dan Loeb on AI, Credit, & Third Point’s $25B Strategy

Click for larger graphic h/t Capital Mischief

* * * * *

Click for larger graphic h/t Tom Kane

* * * * *

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Michael Murphy CFA
Founding Editor
New World Investor

All Recommendations

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First. Isn’t anyone eagerly reading this any more? Or is it just no rush.

I love it!

MM continues to ignore my posts on AKBA. He does no hard financial analysis anymore, except for giving his general, intuitive views on AI and other pure tech stocks. Any subscriber interested in AKBA should follow news closely and buy now at $1.20, or wait until after Q2 ER Aug 6. If Vafseo sales are good but not great, expect a dip in PPS to around $1 or less. It will take Q3 ER 3 months later to recover. But MM’s advice to buy below $4 is useless because it is outdated. That’s akin to choosing to meet a woman online by seeing her 20 year old picture. I know someone who was slender as a teenager. 30 years later, she is now obese.

thanks MM
i appreciate your coverage on PLTR, NVDA. the inflation numbers are entertaining at best. inflation is running strong with no letup in spite of the alternative methods of interpretation. We seem to lack the honesty integrity and will required to deal with inflation.
Has {He} drillers production and exploration surfaced for anyone as an investment theme in response to the state of the world.
pray for September.

The optimism expressed by MM in the first paragraph or two of this Radar Report appear to me to be completely at odds with his comments about oil further down in the Report. Mark my words: Higher oil will lead to higher inflation. My Fox News watching older brother pointed out early in Trump’s ill-advised attacks on Iran that gas prices were even higher after Russia’s giant attack on Kiev under Biden and soon dropped back to normal. As I pointed out to him, at that time there was no destruction of oil infrastructure, unlike what has happened since our bunker busters were deployed. As some of the initial price shock wore off, about a month ago I bought some calls expiring in October expecting higher prices to come. Those calls are up well over 100%, (nearly 200%).

As the war spreads from the Persian Gulf to the Red Sea and Caspian and damages oil infrastructure in numerous countries there is only one direction for oil prices to go. And that will drive overall inflation higher.

Hey Chris what’s your thoughts on capr today

1) SRPT had a very tough time getting FDA approval for its dmd Tx but when they finally got it, it was very rewarding. 
2) If in fact this investment does go south, eventually you will be able to get a substantial recovery from a class action suit
3) Consider doing the same thing I did the last time prices were this low and trads shares for call options which might be crazy cheap

I am considering the reality that CAPR’s Hope 3 data was flawed and the FDA was closer to reality. Assume that Dera works due to the mechanism given the masterly presentation by Ed Marban today. It may work slowly that a 1 year trial is not enough time to see. The cardio trial had patients with average LVEF of 55%, placebo 59%. Normal LVEF in middle age is 60-70%. My patients with 40% are in OK shape. So DMD patients with those LVEF numbers are OK, although on the decline. It may be that 45% might be low enough to see effects. Not discussed by anyone at Adcom was the higher baseline LVEF in placebos. Linda made the mistake of “imputing” or deleting 1 placebo patient who she found out later was taking another anti-fibrotic drug. That patient should have been screened out at the beginning. Linda blew it. Then a cardiologist on the panel said that LV end diastolic volume (LVEDV) was higher in the Dera vs placebo patients. Better heart function has LOWER LVEDV because more blood is pumped by higher LVEF, leaving LVEDV lower. So there was inconsistency in LVEF vs LVEDV. There was also missing cardio data like heart rate, blood pressure, biomarkers like CPK, BNP. So cardio had little evidence for Dera benefit.

PUL was better. Total PUL data had a little too high p value for benefit, but mid PUL was decent. I liked how panel member Dr. Chris Cassidy was vocal about all the focus on technicalities like SAP v1.1 vs v3.0, but was impressed with the videos from real patients. She was the only MD voting yes, although 2 patient advocates also voted yes. Also, the moderator voted no on cardio but was sympathetic towards PUL, esp in a post marketing conditional approval. So it is possible that PUL will get conditional approval, but the odds may be only 25%. Yes, 33% of negative Adcom’s may result in FDA approvals later, but this FDA is unlikely to change their strong objections for even PUL. It would take strong political pressure to get PUL approval. But any politician who strong-arms the FDA may face repercussions if the FDA cries foul.

How long do class action suits take, and how much are investors likely to recover? Tomorrow AM is probably a bad time to sell in the avalanche. Better selling is probably leading up to PDUFA on hopium.

July 27 (Reuters) – U.S. Food and Drug Administration staff reviewers raised ​concerns about the effectiveness data for Capricor Therapeutics’
 cell therapy for a heart ‌condition related to Duchenne muscular dystrophy, dragging the company’s shares 70% lower in early trading.
The briefing documents, released on Monday, raise concerns for the treatment at the FDA’s external advisers’ meeting ​on Wednesday, where the effectiveness and risk-benefit profile of the experimental ​therapy, deramiocel, will be discussed.
Keep up with the latest medical breakthroughs and healthcare trends with the Reuters Health Rounds newsletter. Sign up here.The agency’s staff said that Capricor changed ⁠how it measured the main results after the therapy’s late-stage trial ended, calculating ​arm-function performance as a percentage change instead of the original plan of analyzing ​scores in a 42-point test.
Measurement of heart function was also changed to ranking patients’ results, from monitoring changes in the percentage of blood pumped by the heart with each beat, ​which in medical terms is called left ventricular ejection fraction, the reviewers said ​in their briefing document.
“FDA does not consider the conversion of raw change to percent change ‌and ⁠then back to raw change to have been scientifically justified, as it adds complexity and reduces accuracy,” the agency’s staff said in their briefing document.
The reviewers also questioned whether the trial population had DMD-related cardiomyopathy, noting that patients had normal heart-pumping ​function on average ​at the outset.
Evidence ⁠was limited that enough of the intravenously delivered therapy reached the heart to provide a benefit, they added.
Duchenne muscular dystrophy, or DMD, ​is a rare inherited disease that causes progressive muscle ​weakness and ⁠primarily affects boys.
There are currently no FDA-approved therapies specifically for DMD-associated cardiomyopathy, a form of heart disease that commonly develops as the disease progresses.
Existing Duchenne treatments, including Sarepta ⁠Therapeutics’ (SRPT.O), opens new tab
 ​gene therapy Elevidys and exon-skipping drugs, target the ​underlying cause of the disease rather than the heart complications that develop as patients age.

https://www.capricor.com/investors/news-events/press-releases/detail/349/capricor-comments-on-briefing-materials-ahead-of-july-29

Capricor Therapeutics today provided an update ahead of the Company’s upcoming FDA Advisory Committee meeting, at which an independent advisory committee will discuss Capricor’s Biologics License Application (BLA) for Deramiocel, an investigational cell therapy for the treatment of Duchenne muscular dystrophy (DMD), as part of the FDA’s ongoing review of the application.
 
“Capricor has engaged fully and transparently with the FDA throughout the review process for our Biologics License Application for Deramiocel and has been responsive to every request from the FDA. Our results are governed by the final analysis plan, SAP version 3.0, which was finalized prior to unblinding. It is critical to understand that the post-hoc analyses in the FDA’s briefing materials rely on SAP version 1.1, an unsigned incomplete internal draft which became obsolete with the addition of cohort B and did not include content specifically requested by FDA. The Phase 3 HOPE-3 results demonstrate a statistically significant benefit on the primary endpoint, PUL 2.0, with supportive benefits in cardiac function, and we believe Deramiocel offers a meaningful treatment option for boys and young men living with Duchenne, who continue to face a significant unmet medical need. Ahead of the meeting, we have posted a portion of our slides to accurately frame the discussion for stakeholders on our website,” said Linda Marbán, Ph.D., Chief Executive Officer of Capricor Therapeutics.
 
These materials will be available in the Investors section of the Company’s website shortly.

Capricor’s AdCom slides

chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://d1io3yog0oux5.cloudfront.net/_72aff4e3549771e6878d76942cafb02a/capricor/db/2227/21540/pdf/CAPR+Ad-com+%28select+slides%29.pdf

Could you link it better? Thanks.

Even more drama! Noted sleezebag Shkreli claims CAPR CEO is a fraudster!! (Shkreli is the repeat offender fraudster). Also note there is info about an ongoing lawsuit by CAPR vs. Nippon Shinyaku and its U.S. subsidiary NS Pharma

———————————————-
“QUICK SPARK: Capricor Stock Dives — ‘Complete Fraud’ Says Pharma Bro Martin Shkreli
BENZINGA
Jul-27-2026 12:02 p.m. ET
July 29
‘Pharma Bro’ Martin Shkreli is publicly accusing Capricor Therapeutics (NASDAQ:CAPR) of fraud and alleging legal action will be taken against its CEO and a consultant over patient data.

Shkreli posted on X that “$CAPR is a complete fraud” and later wrote in a separate post that “charges will be brought” on Capricor CEO Linda Marbán and statistics consultant Suzanne Hendrix, claiming they were “playing with patient data.”
Benzinga has reached out to Capricor Therapeutics for comment and will update this story with any response.
<figure class=”wp-block-embed is-type-rich is-provider-x wp-block-embed-x”>

the $CAPR is a complete fraud pic.twitter.com/rj9dm1nX3Z

— Martin Shkreli (@MartinShkreli) July 27, 2026

</figure> <figure class=”wp-block-embed is-type-rich is-provider-x wp-block-embed-x”>

charges will be brought on $CAPR CEO @linda_marban & statistics consultant Suzanne Hendrix. having been myself, i am loathe to recommend prison. in this case, i’m making sure you’re both going. playing with patient data is a line you cannot cross. in my worst hour i’d never.

— Martin Shkreli (@MartinShkreli) July 27, 2026

</figure>
FDA Documents Raise ConcernsCapricor’s stock has been under pressure following the release of FDA briefing documents that questioned the effectiveness of its Duchenne cell therapy. 
On Monday, shares of Capricor plummeted over 60% after the FDA posted these documents ahead of a July 29 advisory committee meeting.
The documents suggested that the data from Capricor’s pivotal HOPE-3 study might not meet the FDA’s standard for substantial evidence of effectiveness, as it relies on a single pivotal Phase 3 trial. This has led to significant weakness in Capricor’s stock.
Legal Dispute with NS PharmaAdding to Capricor’s challenges, the company has filed a lawsuit against Nippon Shinyaku and its U.S. subsidiary NS Pharma. The dispute centers on the distribution agreement for Deramiocel, Capricor’s investigational cell therapy for Duchenne muscular dystrophy.
Capricor alleges that the agreement’s pricing terms could limit patient access to the therapy, particularly for those covered by Medicare, Medicaid, and private insurance plans.
The company is seeking to revise the pricing mechanism to ensure broader access, as detailed in a May 8 report.”

Listening to the FDA advisory committee meeting, the stories of patients in the trial, their parents and others describing the decline of Duchenne patients is heartbreaking. Deramiocel has helped stop the disease’s progress. They are begging to continue access to Deramiocel. They communicate well the importance to continue access to this new med.

Part of the reason I invest in biotechs is the prosocial efforts to help people who need new meds to combat disease. Even if Deramiocel has limited effects overall, the effects on this small group seem life changing. Hopefully the Advisory Committee has a heart (and a brain ;-)!

I found the Adcom people thoughtful and considerate. I didn’t like FDA trickery such as posing 3 questions, and then in the last minute only 1 question about whether members should approve COMPOSITE skeletal and cardio. Cardio was clearly weak, but PUL had a decent chance, certainly for mid arm PUL. I thought the question about sole PUL approval would come next, and it might have gotten at least 7 out of 12 yes votes. But the clock showed 4:55 at the end of the composite question, with no time allowed for the 2nd question. Fucking FDA cheaters.

Maybe I won’t sell out at 1-2, and wait for 6 on PDUFA hopium. Then again, if PUL gets approved, everyone is ignoring the $1 million price tag, which can only be justified if Dera unequivocally has major benefits, so the outlook for company finances is questionable.

The major asset is still Stealth X platform for safer vaccines and other drugs. Someone on ST said yesterday that’s now worth $10. But again the FDA corruption serves the interests of Big Pharma who pays most of the FDA’s income, so BP would want to protect the flawed mRNA and other vaccine technologies.

I will probably abandon biotech stocks due to FDA corruption and never being sure that I can navigate data corruption by CAPR and others. I failed to harvest my 3-4X gains in CAPR. I hold AKBA, ACHV, NGEN for now.

NGEN is a winner. The FDA seems supportive. NGEN is the only game in town for nerve regeneration following injury. Hopefully not another capital raise before their Phase 3 trial is completed. Hopefully a well-run trial, but seems like too many independent trial locations to manage carefully. (Why so many??) ACHV appears to be as close to a sure approval as you can get.

IMHO Capricor ran a sloppy study. Changing the study mid-study without FDA buy-in was asking for trouble. Some of the earlier work p<0.14 results do not reach significance but its a positive trend unlikely just due to just chance. The testimony from patients and parents describing positive benefits of the therapy appears to show some positive effects (for at least some). Can’t approve at this time but doesn’t appear to be a completely ineffective med, either. Perhaps only effective for some symptoms or some patient subtypes?

You probably ran some human psych trials or at least studied them. I consider statistics a dismal “science.” It is classified as a branch of math. Math’s precision makes it the Queen of sciences, and I consider statistics’ highly subjective methods like the wild rodents in the Queen’s court. P of 0.14 means that the odds are 86% that an effect is real and not due to lucky chance. Many things in my life have certainty less than 86%. I don’t know why p of less than 0.05 is declared stat sig and worshipped like the laws of thermodynamics and gravity. Do you know? In the context of a tragic disease like DMD, even p of 0.30 (70% certainty) deserves a right to try, as long as it is safe. I agree with MM who said decades ago that the FDA should just evaluate safety, and leave it to the market to judge efficacy and cost. About efficacy–who decides whether a half or 1 inch increase in erection length is clinically meaningful? It is totally subjective and up to each man to judge. How dare any pompous FDA reviewer make a judgment about what is clinically meaningful and control the fate of desperate DMD patients?

P of 0.14 means that the result would happen that often purely by chance variation. P<0.05 or P<.01 are the typical levels used to trust that an effect was NOT due to chance variation. In other words, “proof” that the result is a real effect.

So I’d say P of 0.14 looks like further research may pay off, if you expanded the number of subjects, tried various dosages, or controlled other conditions better. But not certain…otherwise why didn’t they already run more subjects or tried a variety of dosages? Cost and risk of side effects?

But P values in other calculations were not as good, so maybe the effect of the drug is minimal or only for a small subset of patients or ….? Who knows? Its very expensive to run larger numbers of patients, or run multiple experiments. And it’s risky. They noted that some side effects were not trivial. The FDA could get fried if they approved a drug that caused problems they didn’t detect in trials.

However, the testimony of patients clearly is inconsistent with the notion that this med does not work. Okay, this is not a “random sample” or complete sample of all the patients who got the drug, just the people who chose to show up to testify. Maybe it only works for a subset of patients? Or we don’t know what else is needed for this med to work well? Maybe these patients would have not deteriorated as much for other reasons? There is no fixed amount of deterioration that occurs for everybody?

Seems to me they should do more analysis and trials, but they may put their resources elsewhere. They also should be careful NOT to run an FDA trial as if they are doing exploratory research, modifying things during the trial etc. That will just piss off the FDA evaluators.

Look at the YouTube video of the 7/29 Adcom. It’s almost 8 hours, including two 30 min breaks. Most important to me is at 1:27:00 where Dr. Craig McDonald, the rehab expert who has treated lots of DMD patients and the lead author of the positive Lancet article that came out AM 7/29 discusses PUL findings. The hand to mouth task is a component of PUL criteria. A score of 2 is normal, 1 requires assistance which is analogous to healthy people trying to lift a glass of water using 2 feet feet to mouth. Almost none of us could do it without spilling, so we would die of dehydration unless another person fed us. Dr. McD found only 1 of 64 Dera patients deteriorated from 2 to 1 in Hope 3, whereas 11 of 27 placebos went from 2 to 1. It is well established that loss of 1 point is a bad outcome, and Hope 3 was hugely significant. At 1:31:00, Dr. Jonathan Soslow, the leading cardiologist treating DMD said that cardio was positive in Hope 3. He acknowledged that there was missing data. That was not from negligence on the part of CAPR, but from the difficulty in lifting patients into the MRI machine, having them hold their breath, lie still. (I had an MRI of abdomen a few years ago. There were many times I held my breath for the required 20 sec, but at the end I had to hold it for 1 min, which I barely could do.)

My summary is that the FDA sabotaged the proceedings of the Adcom. Some thoughtful Adcom members were sympathetic to the idea that skeletal data was good and even the heartless statisticians said they were moved by the patient videos. BUT, despite lip service to their regulatory flexibility by considering total evidence–statistical + anecdotes–in the end, they did NOT allow voting on skeletal benefits, but merely asked about cardio. The FDA did not acknowledge the valuable expertise of Drs. McD and Soslow who said Hope 3 was positive for both skeletal and cardio. Instead, the FDA dogmatically pushed their stat sig and SAP religion finding CAPR heretical. Asher77 on Stocktwits makes excellent points supporting the validity of CAPR’s data. He is a perceptive basic scientist.

The vocal DMD community and some politicians such as Sen Ron Johnson will push for FDA oversight, so Dera probably will be eventually approved. As investors, what to do? D-day is 8/22 or before. If FDA rejection occurs, the fair value is the cash, just below $5 pps. Cash goes down by $0.50-1.00 per quarter, I forgot. But cash will be conserved by layoffs, so I don’t see pos much below $4 for a while. Still, the negativity may see a somewhat sustained push down to below $3. There have been traders who bought below $3 and sold above $4 in the past week. Suppose Linda makes some good moves, like re-applying under a supplemental BLA for skeletal only, esp with accelerated approval requiring post-market monitoring. Approval may come 6 months later. As MM has said, it is often hard to sell and then gracefully get back in at a lower price, so maybe the best thing to do is hold for $15-25 in 2027. My cost is $8, so I presently don’t have as much losses as giddy people who happily added at $25.

The only slightly bright spot for me was having a GTC order in advance at $16. It opened below $6 on 7/30 and I got filled at $5.82.

If the FDA did indeed sabotage the proceedings, why would there be any hope that things could/would change? I’ve been involved with a company or two with similar circumstances, and I don’t think they ever got approved. What benefit does the FDA get from this action? Money?

what do you realistically believe will happen?

Yes, coming back to a stubborn FDA probably won’t change things, which is why the stock is now trading for cash value. If the FDA lived by its word that the entire Adcom meeting would be taken seriously outside of the narrow vote for cardio only, there would be great odds of approval, esp for skeletal only.

What do I mean by “sabotage”? That means evil intent, which is possible if a big Pharma wanted to buy CAPR at a much lower price and paid the FDA to participate in this complicity. Yes, “money” as you say. You know this happens. Alternatively, I probably should say “negligent” instead of “sabotage.” Many doctors make mistakes, but they don’t deliberately try to kill patients. They are guilty of negligence, but not sabotage. Statisticians twist the numbers by using different methodologies. The FDA insisted on using SAP1.1 and refused to accept CAPR’s justification to use SAP3.0. In short, SAP1.1 is obsolete because it didn’t consider cohort B which had much higher incidence of cardiomyopathy than cohort A.

Why do many smart people remain stubborn? They have intellectual pride in their original position, and don’t admit they have overlooked some evidence. Look at MM who is usually insightful, but he maintains his out of date buy prices for AKBA. Many bulls like me call the FDA out on their stubbornness. Asher77 on Stocktwits is more scholarly than I, and he factually calls out the FDA on their incorrect analysis. Linebacker04 is level headed and still bullish.

If you think CAPR is hopeless, IMO don’t sell below $3.50. But with the right political pressure, this can go to $15 or much higher. I don’t know when. The wild card is the transcendental StealthX exosome platform where CAPR has already done basic development and is awaiting govt funded trials for vaccines and cancer treatments using natural anti-inflammatory factors. Vaccine antigens may have safer delivery via exosomes vs toxic lipid nanoparticles and uncontrolled mRNA transcription. Big Pharma will partner with CAPR for StealthX, or more likely, buy out CAPR entirely for much higher than current $4.20. The best hope for DMD patients is probably Big Pharma greasing the FDA to get Dera approval done at least for skeletal. PUL data is decent, and the video evidence from the patients is convincing that Dera works.

Correction. For PUL as discussed by Dr. McD, 1/24 (not 64) of Dera patients deteriorated from 2 (normal) to 1 (markedly impaired) in 1 year vs 11/27 placebo patients. Astounding p values of less than 0.02 for crucial hand to mouth component of PUL, ignored by FDA. Listen and watch the video from 1:18:00 to !:41:00 from McD and Soslow. Soslow shows a compendium of outside research that absolute LVEF doesn’t easily predict mortality benefits, but trends of LVEF change do.

I emailed the following in support of approval of Deramiocel–Robert.KennedyJr@hhs.gov, Stefanie.Spear@hhs.gov. On Stocktwits, poster patatechaude on Aug 3 had a link.

Sorry to say, I sold all just now at $3.97. The FDA is a criminal enterprise. Like a totalitarian dictator who doesn’t permit reasoned debate from people much more knowledgeable than the FDA, like MD experts, and even logical ST posters. I just saw the movie, The Odyssey with Matt Damon in the lead as Odysseus. The movie was violent, and Odysseus lost many men to the wild creatures, but he survived to see a happy ending. I believe Dera will one day get approved, probably by a BP who buys CAPR and knows how to deal with criminals and has the money to pay them. I have to wait until 31 days to buy at lower prices to capture deductions for losses. Linda lost her request to delay the NS case for 6 weeks beyond 8/10, not that it really matters. She will get a CRL on or before 8/22. In the hands of CAPR, the criminal FDA will reject Dera again even for skeletal. How long and will political influence have any effect? When will the BP buy out CAPR? There will be time to get back in CAPR at lower prices.

All eyes on AKBA after today’s market close.

Last edited 9 days ago by JGMD

Akba,here we go again earnings didn’t seem that bad not enough to warrant a drop like this

What’s your thought on the report

Maybe I’ve lost my mind on CAPR, but tonight on Stocktwits people are high on hopium. REPL got accelerated conditional approval with post-market studies for their advanced melanoma therapy. It had been rejected twice already. The trial was single arm, not as good as CAPR’s double blind placebo trial. But REPL had a positive Adcom saying the drug has possibilities in the terrible melanoma disease. There was supposedly a White House meeting, and the FDA was schooled to play ball. Personally, I believe in CAPR’s data and their justification for their SAP3.0 analysis, but I sold on the basis of thinking it is futile to fight a criminal FDA that has agendas in favoring Big Pharma. Big Pharma is worried that exosome technology as a new way of fighting many diseases will make obsolete their old ways, like the horse and buggy fighting new engine tech. BP will probably buy CAPR for exosomes in StealthX and Dera for DMD. BP may be gaming to buy CAPR at a fire sale low price.

Tomorrow there will possibly be a bounce in CAPR stock.

INO – it’s time, once again, for INO’s quarterly public offering to extend their cash position another quarter down the road.

This time 21,052,632 shares and accompanying warrants to purchase up to 42,105,264 shares at $0.95 per share of common stock and accompanying warrant to purchase two shares of common stock plus a 15% underwriter an option for the same.

This should get them through to FDA approval but I wouldn’t be surprised to see them do an additional capital raise in Q4 to build funds for the launch of INO-3107.

Another reverse split is also now in play.

https://ir.inovio.com/news/news-details/2026/INOVIO-Announces-Pricing-of-20-0-Million-Public-Offering/default.aspx

its gone down and down and continues to split EVEN if they get approval -still would be tough to break even!! on any pop i will be punting!

it seems that we are continually told to bottom fish ——- which can be very dangerous – you can lose your hook – line – and sinker – i prefer safer biotechs like BIIB – WGS and TGTX

SCYX – where there is smoke – there is fire

I always thought the clinical data on SCYX wasn’t exciting, despite the hype about the newest anti fungal drug in 20 years.

I made 6X in TGTX, selling 1-2 years ago at $36. IMO it is a boring blue chip wannabe. It’s still a one trick pony. You’re better off with a Big Pharma like Pfizer. Big Pharmas can get the FDA to do what they want. CAPR is a victim of BP sabotage. A good strategy is to only invest in biotechs that are already partnered with BP. BP can get FDA approvals.

AKBA bites the dust again. Growth in V sales but slightly greater decline in A sales. The pipeline is promising, but totally speculative at early stages. Below $1 in after hours. Danger of reverse splits. Watch MM spin this in tomorrow’s RR. “Buy below $4, blah blah.” I’m not putting any more $ into bios. Criminal FDA + bad managements + financial risks of trials = bad investments. New money into SPY. Let’s share ideas for safe investments. AKBA needs to partner with BP to save cash and to get FDA approval for pipeline in a few years. Otherwise, BK.

AKBA- Pathetic attempt of mgmt to change the narrative and have the market focus just on the pipeline. That is really all they talked about. They also highlighted the continuous decline in Aurixia sales and the lower revenues in 2027 due to the end of TDAPA in 5 months. They offered zero plans of action to offset the end of the subsidies or to convince DaVita to speed up adoption. Re DaVita they confirmed no revenues in the current quarter, as if we needed any more negatives.
They will eventually need capital for the pipeline clinical trials so even if DaVita comes onboard the upside will be limited by dilutive secondaries.

My BP/FDA corruption proof ideas: AU and AG exploded today possibly ending their 7 month correction. If that is the case, very big upside is possible.
Etfs: GLD, SLV, GDX, SIL, GDXJ.
Ind. Stocks: NG, SA, AG.

Agree about gold and silver. Those ETF’s are the safest way to play. For more potential upside, I have my managed account with Sprott. For those like me over 70, they don’t buy exploration and development stocks. In my account, they have junior producers which offer leverage to commodities.

If someone wants to play small bios, the only acceptable way are those companies that are partnered with a big pharma. The BP has the clout to deal with the criminal FDA and other regulatory agencies. The small bio maintains cash and doesn’t get killed as much from dilutions.

Thanks for all your insights.

Jgmd,your call was right on point with AKBA after earnings assuming everyone here is sitting tight,anyone adding to their position

I sold all my AKBA at 0.99 this AM. I was watching premarket trading, steady at 0.99. So I put in GTC limit sell at 0.99. A few minutes before 9:30 AM, premarket showed 0.89-90. It spiked down to 0.85. I thought that shorts sold in premarket at 0.99, then shorted and covered at 0.85 and higher. It rapidly rebounded. A few min later, it peaked at 1.01. Then back down to mid 90’s. I was relatively lucky. In the next 1-2 months, it may rebound to 1.25 if you’re lucky. When Q3 is reported around early Nov, expect V sales to increase, and A sales to decrease, for much the same losses as Q2. It will sell off again. My main concern was TDAPA expiration 12/31/26. Even though script numbers for V are expected to increase a lot due to VOICE and Davita and maybe Fresenius getting on board, the V price will drop hugely from 15K to 2K, so 2027 total revenues are forecast to drop from 2026. The bottom may be 0.50 upon a mediocre Q1 2027 earnings report in early May 2027. AKBA will be forced to cut expenses although not the greedy JB’s undeserved exorbitant salary and bonuses. If anyone wants to play the future, I like the pipeline. It can be advanced with a big pharma taking the risk, and AKBA can get good royalties. The long term target is anyone’s guess. But there is high risk of a reverse split in 2026, which may yield a bottom in the pennies. Watch MM say, “buy up to $4, but for a 10 fold reverse split, that is equivalent to 0.40 in today’s conditions. If he says tonight, “buy up to $4” you know what I think.

PPS is 0.91 as I write this 10:31.